Introducing N-Heteroaromatic Bases into Copper(II) Thiosemicarbazon Complexes: A Way to Change their Biological Activity.

Autor:	Ulchina I; Laboratory of Advanced Materials in Biofarmaceutics and Technics, Moldova State University, Chişinău, 2009, Republic of Moldova., Graur V; Laboratory of Advanced Materials in Biofarmaceutics and Technics, Moldova State University, Chişinău, 2009, Republic of Moldova., Tsapkov V; Laboratory of Advanced Materials in Biofarmaceutics and Technics, Moldova State University, Chişinău, 2009, Republic of Moldova., Chumakov Y; Laboratory of Physical Methods of Solid State Investigation 'Tadeusz Malinowski', Institute of Applied Physics, Chişinău, 2028, Republic of Moldova., Garbuz O; Laboratory of Advanced Materials in Biofarmaceutics and Technics, Moldova State University, Chişinău, 2009, Republic of Moldova.; Institute of Zoology, Academy of Sciences of Moldova, Chişinău, 2028, Republic of Moldova., Burduniuc O; State University of Medicine and Pharmacy 'Nicolae Testemiţanu', Chişinău, 2004, Republic of Moldova., Ceban E; State University of Medicine and Pharmacy 'Nicolae Testemiţanu', Chişinău, 2004, Republic of Moldova., Gulea A; Laboratory of Advanced Materials in Biofarmaceutics and Technics, Moldova State University, Chişinău, 2009, Republic of Moldova.
Jazyk:	angličtina
Zdroj:	ChemistryOpen [ChemistryOpen] 2022 Dec; Vol. 11 (12), pp. e202200208.
DOI:	10.1002/open.202200208
Abstrakt:	Three new copper(II) complexes, [Cu(1,10-Phen)(L)] (1), [Cu(2,2'-Bpy)(L)] (2) and [Cu(3,4-Lut)(L)] (3), where H 2 L=2-[(2,4-dihydroxyphenyl)methylidene]-N-(prop-2-en-1-yl)hydrazine-1-carbothioamide, 1,10-Phen=1,10-phenanthroline, 2,2'-Bpy=2,2'-bipyridine, 3,4-Lut=3,4-lutidine, have been synthesized and characterized by elemental analysis, FTIR spectroscopy and single crystal X-ray crystallography (1, 2). All compounds are mononuclear. The introduction of a monodentate N-heteroaromatic base (3,4-dimethylpyridine) has led to a significant increase of antimicrobial activity against Gram-negative Escherichia coli and antifungal activity against Candida albicans compared to the pro-ligand and the precursor complex [Cu(L)H 2 O]. The introduction of bidentate N-heteroaromatic bases did not lead to such increase of antimicrobial and antifungal activities. Moreover, complex 3 surpasses the inhibitory activity of tetracycline toward Enterobacter cloacae and the inhibitory activity of fluconazole toward Candida parapsilosis and Cryptococcus neoformans. The study of antioxidant activity against cation radicals ABTS⋅ + showed that complexes 1-3 are more active than Trolox, but only introduction of the monodentate N-heteroaromatic base (3,4-dimethylpyridine) led to the increase of antioxidant properties compared to the precursor complex. (© 2022 The Authors. Published by Wiley-VCH GmbH.)
Databáze:	MEDLINE
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