Plasma osteopontin relates to myocardial fibrosis and steatosis and to immune activation among women with HIV.

Autor:	Robinson JA; Department of Microbiology, Immunology, and Inflammation, Center for Neurovirology and Gene Editing, Lewis Katz School of Medicine at Temple University, Philadelphia, PA., Toribio M; Metabolism Unit, Division of Endocrinology., Quinaglia T; Cardiovascular Imaging Research Center (CIRC), Department of Radiology and Division of Cardiology., Awadalla M; Cardiovascular Imaging Research Center (CIRC), Department of Radiology and Division of Cardiology., Talathi R; Metabolism Unit, Division of Endocrinology., Durbin CG; Metabolism Unit, Division of Endocrinology., Alhallak I; Metabolism Unit, Division of Endocrinology., Alagpulinsa DA; Vaccine and Immunotherapy Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Fourman LT; Metabolism Unit, Division of Endocrinology., Suero-Abreu GA; Cardiovascular Imaging Research Center (CIRC), Department of Radiology and Division of Cardiology., Nelson MD; Applied Physiology and Advanced Imaging Laboratory, Department of Kinesiology, University of Texas at Arlington, Arlington, TX., Stanley TL; Metabolism Unit, Division of Endocrinology., Longenecker CT; Division of Cardiology and Department of Global Health, University of Washington, Seattle, WA., Szczepaniak LS; MRS Consulting in Biomedical Research, Albuquerque, NM., Jerosch-Herold M; Division of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Neilan TG; Cardiovascular Imaging Research Center (CIRC), Department of Radiology and Division of Cardiology., Zanni MV; Metabolism Unit, Division of Endocrinology., Burdo TH; Department of Microbiology, Immunology, and Inflammation, Center for Neurovirology and Gene Editing, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Jazyk:	angličtina
Zdroj:	AIDS (London, England) [AIDS] 2023 Feb 01; Vol. 37 (2), pp. 305-310. Date of Electronic Publication: 2022 Nov 03.
DOI:	10.1097/QAD.0000000000003417
Abstrakt:	Objective: Women with HIV (WWH) have heightened heart failure risk. Plasma OPN (osteopontin) is a powerful predictor of heart failure outcomes in the general population. Limited data exist on relationships between plasma OPN and surrogates of HIV-associated heart failure risk. Design: Prospective, cross-sectional. Methods: We analyzed relationships between plasma OPN and cardiac structure/function (assessed using cardiovascular magnetic resonance imaging) and immune activation (biomarkers and flow cytometry) among 20 WWH and 14 women without HIV (WWOH). Results: Plasma OPN did not differ between groups. Among WWH, plasma OPN related directly to the markers of cardiac fibrosis, growth differentiation factor-15 (ρ = 0.51, P = 0.02) and soluble interleukin 1 receptor-like 1 (ρ = 0.45, P = 0.0459). Among WWH (but not among WWOH or the whole group), plasma OPN related directly to both myocardial fibrosis (ρ = 0.49, P = 0.03) and myocardial steatosis (ρ = 0.46, P = 0.0487). Among the whole group and WWH (and not among WWOH), plasma OPN related directly to the surface expression of C-X3-C motif chemokine receptor 1 (CX3CR1) on nonclassical (CD14-CD16+) monocytes (whole group: ρ = 0.36, P = 0.04; WWH: ρ = 0.46, P = 0.04). Further, among WWH and WWOH (and not among the whole group), plasma OPN related directly to the surface expression of CC motif chemokine receptor 2 (CCR2) on inflammatory (CD14+CD16+) monocytes (WWH: ρ = 0.54, P = 0.01; WWOH: ρ = 0.60, P = 0.03), and in WWH, this held even after controlling for HIV-specific parameters. Conclusion: Among WWH, plasma OPN, a powerful predictor of heart failure outcomes, related to myocardial fibrosis and steatosis and the expression of CCR2 and CX3CR1 on select monocyte subpopulations. OPN may play a role in heart failure pathogenesis among WWH. Clinicaltrialsgov Registration: NCT02874703. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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