| Autor: |
Upadhyay RP; Centre for Health Research and Development, Society for Applied Studies, New Delhi, India.; Department of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway., Taneja S; Centre for Health Research and Development, Society for Applied Studies, New Delhi, India., Strand TA; Department of Research, Innlandet Hospital Trust, Lillehammer, Norway., Hysing M; Department of Psychosocial Science, Faculty of Psychology, University of Bergen, Bergen, Norway., Koshy B; Department of Developmental Pediatrics, Christian Medical College, Vellore, India., Bhandari N; Centre for Health Research and Development, Society for Applied Studies, New Delhi, India., Bahl R; Department of Maternal, Newborn, Child and Adolescent Health, World Health Organization, Geneva, Switzerland. |
| Jazyk: |
angličtina |
| Zdroj: |
The British journal of nutrition [Br J Nutr] 2023 Sep 14; Vol. 130 (5), pp. 868-877. Date of Electronic Publication: 2022 Dec 21. |
| DOI: |
10.1017/S0007114522003944 |
| Abstrakt: |
Inadequate protein intake and lack of micronutrients may affect neurodevelopment in infants. This randomised controlled trial was conducted to measure the effect of two milk-cereal mixes with modest and high amounts of protein and enriched with multiple micronutrients, given between 6 and 12 months, on cognitive, language, motor and behavioural scores at 12 and 24 months of age, compared with no-supplementation. The two supplements were also compared with each other. The study was conducted in urban Delhi, India, and the infants were randomised in a 1:1:1 ratio to the three study groups. At 12 and 24 months of age, 1134 and 1214 children were available, respectively. At 12 months of age, compared with no-supplement group, an increase in the motor scores (mean difference, MD 1·52, 95 % CI: 0·28, 2·75) and a decrease in the infant temperament scores (MD - 2·76, 95 % CI: -4·23, -1·29) in the modest-protein group was observed. Those in the high-protein group had lower socio-emotional scores (MD - 1·40, 95 % CI: -2·43, -0·37) and higher scores on Infant Temperament Scale (MD 2·05, 95 % CI: 0·62, 3·48) when compared with modest-protein group. At 24 months, no significant differences in any of the neurodevelopment scores between the three study groups was found. In conclusion, supplementation with modest amount of protein and multiple micronutrients may lead to short-term small improvements in motor function and infant temperament. There appears no advantage of supplementing with high protein, rather negative effects on infant behaviour were observed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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