Quantitative Dual-Energy CT Image Guidance for Thermochemical Ablation: In Vivo Results in the Rabbit VX2 Model.

Autor:	Thompson EA; Department of Imaging Physics, the University of Texas MD Anderson Cancer Center, Houston, Texas., Fowlkes NW; Department of Veterinary Medicine and Surgery, the University of Texas MD Anderson Cancer Center, Houston, Texas., Jacobsen MC; Department of Imaging Physics, the University of Texas MD Anderson Cancer Center, Houston, Texas., Layman RR; Department of Imaging Physics, the University of Texas MD Anderson Cancer Center, Houston, Texas., Cressman ENK; Department of Interventional Radiology, the University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: ecressman@mdanderson.org.
Jazyk:	angličtina
Zdroj:	Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2023 May; Vol. 34 (5), pp. 782-789. Date of Electronic Publication: 2022 Dec 17.
DOI:	10.1016/j.jvir.2022.12.026
Abstrakt:	Purpose: To evaluate the feasibility of using dual-energy computed tomography (CT) and theranostic cesium hydroxide (CsOH) for image guidance of thermochemical ablation (TCA) in a rabbit VX2 tumor model. Materials and Methods: In vivo experiments were performed on New Zealand white rabbits, where VX2 tumor fragments (0.3 mL) were inoculated into the right and left flanks (n = 16 rabbits, 32 tumors). Catheters were placed in the approximate center of 1- to 2-cm diameter tumors under ultrasound guidance. TCA was delivered in 1 of 3 treatment groups: untreated control, 5-M TCA, or 10-M TCA. The TCA base reagent was doped with 250-mM CsOH. Dual-energy CT was performed before and after TCA. Cesium (CS)-specific images were postprocessed on the basis of previous phantom calibrations to determine Cs concentration. Line profiles were drawn through the ablation center. Twenty-four hours after TCA, subjects were euthanized, and the resulting damage was evaluated with histopathology. Results: Cs was detected in 100% of treated tumors (n = 21). Line profiles indicated highest concentrations at the injection site and decreased concentrations at the tumor margins, with no Cs detected beyond the ablation zone. The maximum detected Cs concentration ranged from 14.39 to 137.33 mM. A dose-dependent trend in tissue necrosis was demonstrated between the 10-M TCA and 5-M TCA treatment groups (P = .0005) and untreated controls (P = .0089). Conclusions: Dual-energy CT provided image guidance for delivery, localization, and quantification of TCA in the rabbit VX2 model. (Copyright © 2022 SIR. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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