99m Tc Bone-Avid Tracer Cardiac Scintigraphy: Role in Noninvasive Diagnosis of Transthyretin Cardiac Amyloidosis.

Autor:	Khor YM; From the Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore (Y.M.K.); Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (Y.M.K., V.S., M.F.D.C., S.D.), Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine (S.A.M.C., R.H.F., S.D.), and CV Imaging Program, Cardiovascular Division and Department of Radiology (S.A.M.C., V.S., M.F.D.C., S.D.), Brigham and Women's Hospital and Harvard Medical School, 70 Francis St, Boston, MA 02115; and Midwest Heart and Vascular Specialists, HCA Midwest Health, Kansas City, Mo (V.S.)., Cuddy SAM; From the Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore (Y.M.K.); Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (Y.M.K., V.S., M.F.D.C., S.D.), Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine (S.A.M.C., R.H.F., S.D.), and CV Imaging Program, Cardiovascular Division and Department of Radiology (S.A.M.C., V.S., M.F.D.C., S.D.), Brigham and Women's Hospital and Harvard Medical School, 70 Francis St, Boston, MA 02115; and Midwest Heart and Vascular Specialists, HCA Midwest Health, Kansas City, Mo (V.S.)., Singh V; From the Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore (Y.M.K.); Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (Y.M.K., V.S., M.F.D.C., S.D.), Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine (S.A.M.C., R.H.F., S.D.), and CV Imaging Program, Cardiovascular Division and Department of Radiology (S.A.M.C., V.S., M.F.D.C., S.D.), Brigham and Women's Hospital and Harvard Medical School, 70 Francis St, Boston, MA 02115; and Midwest Heart and Vascular Specialists, HCA Midwest Health, Kansas City, Mo (V.S.)., Falk RH; From the Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore (Y.M.K.); Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (Y.M.K., V.S., M.F.D.C., S.D.), Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine (S.A.M.C., R.H.F., S.D.), and CV Imaging Program, Cardiovascular Division and Department of Radiology (S.A.M.C., V.S., M.F.D.C., S.D.), Brigham and Women's Hospital and Harvard Medical School, 70 Francis St, Boston, MA 02115; and Midwest Heart and Vascular Specialists, HCA Midwest Health, Kansas City, Mo (V.S.)., Di Carli MF; From the Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore (Y.M.K.); Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (Y.M.K., V.S., M.F.D.C., S.D.), Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine (S.A.M.C., R.H.F., S.D.), and CV Imaging Program, Cardiovascular Division and Department of Radiology (S.A.M.C., V.S., M.F.D.C., S.D.), Brigham and Women's Hospital and Harvard Medical School, 70 Francis St, Boston, MA 02115; and Midwest Heart and Vascular Specialists, HCA Midwest Health, Kansas City, Mo (V.S.)., Dorbala S; From the Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore (Y.M.K.); Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (Y.M.K., V.S., M.F.D.C., S.D.), Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine (S.A.M.C., R.H.F., S.D.), and CV Imaging Program, Cardiovascular Division and Department of Radiology (S.A.M.C., V.S., M.F.D.C., S.D.), Brigham and Women's Hospital and Harvard Medical School, 70 Francis St, Boston, MA 02115; and Midwest Heart and Vascular Specialists, HCA Midwest Health, Kansas City, Mo (V.S.).
Jazyk:	angličtina
Zdroj:	Radiology [Radiology] 2023 Feb; Vol. 306 (2), pp. e221082. Date of Electronic Publication: 2022 Dec 20.
DOI:	10.1148/radiol.221082
Abstrakt:	Transthyretin cardiac amyloidosis (ATTR-CA) is an overlooked cause of heart failure, with substantial morbidity and mortality. The emergence of several novel therapies has fueled the interest in early and accurate diagnosis of ATTR-CA so that potentially life-saving pharmacologic therapy can be administered in a timely manner. The most promising imaging modality and biomarker is SPECT imaging with technetium 99m ( 99m Tc)-radiolabeled bone-seeking tracers, which have high specificity in the diagnosis of ATTR-CA, potentially obviating biopsy. In this article, the authors provide a focused review on the use of 99m Tc pyrophosphate (PYP), 3,3-diphosphono-1,2-propanodicarboxylic acid (DPD), and hydroxymethylene diphosphonate (HMDP) for diagnosis of ATTR-CA, present a systematic approach to interpretation of the scans, and highlight several common pitfalls to illustrate important diagnostic principles for accurate interpretation of these images. The authors indicate when to use endomyocardial biopsy for the diagnosis of cardiac amyloidosis and conclude with a section on quantitation of 99m Tc-PYP/DPD/HMDP imaging. (© RSNA, 2022.)
Databáze:	MEDLINE
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