Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review.

Autor:	Spinella A; At University Hospital of Modena, Italy, Amelia Spinella, MD, PhD, is Medical Consultant, Rheumatology Unit; Marco de Pinto, MD, is Resident, Rheumatology Unit; Carlo Baraldi, PhD, is Medical Consultant, Medical Toxicology-Headache and Drug Abuse Research Center; Claudio Galluzzo, MD, is Resident, Rheumatology Unit; Sofia Testoni, MD, is Resident, Rheumatology Unit; Federica Lumetti, MD, is Medical Assistant, Rheumatology Unit; Luca Parenti, RN, is Nurse and Data Manager, Rheumatology Unit; Simona Guerzoni, MD, is Medical Consultant, Medical Toxicology-Headache and Drug Abuse Research Center; Carlo Salvarani, MD, is Full Professor and Head of Department; and Dilia Giuggioli, MD, PhD, is Associate Professor, Rheumatology Unit., de Pinto M, Baraldi C, Galluzzo C, Testoni S, Lumetti F, Parenti L, Guerzoni S, Salvarani C, Giuggioli D
Jazyk:	angličtina
Zdroj:	Advances in skin & wound care [Adv Skin Wound Care] 2023 Jan 01; Vol. 36 (1), pp. 18-23.
DOI:	10.1097/01.ASW.0000891856.08360.61
Abstrakt:	Objective: To explore the effect of topical cannabidiol (CBD) in treating digital ulcers in patients with systemic sclerosis (SSc). Methods: In total, 45 patients with SSc who had digital ulcers were consecutively enrolled between January 2019 and December 2019. Of the participants, 25 were treated with CBD during surgical debridement and 20 were treated with standard local therapy. A numeric rating scale for pain and Health Assessment Questionnaire Disability Index were administered at the baseline and at the end of treatment. Results: Local treatment with CBD was significantly associated with lower pain scores, higher health assessment scores, and an increase in participants' total hours of sleep. Patients in the control group more frequently required additional analgesic therapy. Conclusions: Topical CBD may be a valuable tool to treat pain related to digital ulcers in patients with SSc. (Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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