Presentation of SLE after COVID vaccination in a pediatric patient.

Autor: Nelson MC; Division of Pediatric Rheumatology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. mcorri3@emory.edu.; Children's Healthcare of Atlanta, Atlanta, USA. mcorri3@emory.edu., Rytting H; Division of Pathology, Children's Healthcare of Atlanta, Atlanta, USA., Greenbaum LA; Children's Healthcare of Atlanta, Atlanta, USA.; Division of Pediatric Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA., Goldberg B; Division of Pediatric Rheumatology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Children's Healthcare of Atlanta, Atlanta, USA.
Jazyk: angličtina
Zdroj: BMC rheumatology [BMC Rheumatol] 2022 Dec 20; Vol. 6 (1), pp. 81. Date of Electronic Publication: 2022 Dec 20.
DOI: 10.1186/s41927-022-00313-8
Abstrakt: Background: The outbreak of severe acute respiratory syndrome coronavirus 2 has had an enormous impact on global health. Vaccination remains one of the most effective interventions for disease prevention. Clinically significant vaccine side effects are uncommon, though autoimmune-mediated disease occurs in a small percentage of vaccine recipients. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that is associated with significant morbidity and mortality. Childhood-onset SLE tends to have more severe disease manifestations than adult-onset SLE. In adults, there are a few reported cases of SLE developing soon after coronavirus disease 2019 (COVID-19) mRNA vaccination.
Case Presentation: A 14-year-old previously healthy male developed laboratory and clinical evidence of SLE, including maculopapular malar rash, arthritis, pleuritic chest pain, and class V (membranous) lupus nephritis, 2 days after his third dose of the Pfizer-BioNTech COVID-19 vaccine. The patient's symptoms improved after initiation of prednisone and mycophenolate mofetil. We also summarize eleven prior case reports describing SLE after COVID-19 vaccine in adults.
Conclusion: To our knowledge, this is the first reported pediatric patient with new onset SLE following COVID-19 mRNA vaccination. While potential mechanistic links exist between COVID-19 vaccination and SLE development, additional studies are necessary to elucidate the exact nature of this relationship.
(© 2022. The Author(s).)
Databáze: MEDLINE
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