Sporothrix pathogenic clade: Molecular analysis of animal and human clinical isolates.

Autor:	Ribeiro-Marques MD; Department of Dermatological, Infectious, and Parasitic Diseases, São José do Rio Preto School of Medicine (FAMERP), São José do Rio Preto, São Paulo,Brazil., Maschio-Lima T; Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, São Paulo,Brazil., Lemes TH; Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, São Paulo,Brazil., Siqueira JPZ; Department of Dermatological, Infectious, and Parasitic Diseases, São José do Rio Preto School of Medicine (FAMERP), São José do Rio Preto, São Paulo,Brazil., Brizzotti-Mazuchi NS; Department of Dermatological, Infectious, and Parasitic Diseases, São José do Rio Preto School of Medicine (FAMERP), São José do Rio Preto, São Paulo,Brazil., Caetano MH; Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, São Paulo,Brazil., Almeida BG; Department of Dermatological, Infectious, and Parasitic Diseases, São José do Rio Preto School of Medicine (FAMERP), São José do Rio Preto, São Paulo,Brazil., Mozaner LQ; Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, São Paulo,Brazil., Monteiro RC; Department of Microbiology, Immunology and Parasitology, Laboratory of Emerging Fungal Pathogens, Federal University of São Paulo, São Paulo, São Paulo, Brazil., Camargo ZP; Department of Microbiology, Immunology and Parasitology, Laboratory of Emerging Fungal Pathogens, Federal University of São Paulo, São Paulo, São Paulo, Brazil., Rodrigues AM; Department of Microbiology, Immunology and Parasitology, Laboratory of Emerging Fungal Pathogens, Federal University of São Paulo, São Paulo, São Paulo, Brazil., Gottardo de Almeida MT; Department of Dermatological, Infectious, and Parasitic Diseases, São José do Rio Preto School of Medicine (FAMERP), São José do Rio Preto, São Paulo,Brazil.; Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, São Paulo,Brazil.
Jazyk:	angličtina
Zdroj:	Medical mycology [Med Mycol] 2022 Dec 29; Vol. 61 (1).
DOI:	10.1093/mmy/myac096
Abstrakt:	Sporotrichosis is a subcutaneous mycosis that affects animals and humans. Varying in severity, occurrences range from local lesions to systemic involvement. It is caused by thermodimorphic and saprobic fungi from the Sporothrix pathogenic clade. This study aimed to identify the species and the sexual idiomorph distribution patterns responsible for diagnosed cases of sporotrichosis in São José do Rio Preto, Brazil. We included 188 isolates of Sporothrix sp. from feline lesions and 27 of human origin, which underwent molecular identification and genotyping for mating-type MAT1-1 and MAT1-2. The results showed that Sporothrix brasiliensis is the prevalent species in feline sporotrichosis outbreaks with the overwhelming presence of a single mating-type, MAT1-2 (P <.0001), suggesting a prevalently clonal form of spread. Morphological analyses did not discriminate among cryptic species in the genus Sporothrix, and molecular identification was essential for the correct identification of the species responsible for the observed cases of sporotrichosis. Distribution analyses of MAT1-2 isolates support the hypothesis of unidirectional migration from the current epidemics in São Paulo and Rio de Janeiro to the municipality of São José do Rio Preto. (© The Author(s) 2022. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.)
Databáze:	MEDLINE
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