Bisphenol A exacerbates anxiety-like behavior and neuroinflammation in prefrontal cortex of adult obese mice.

Autor: Lama A; Department of Pharmacy, University of Naples Federico II, Naples, Italy., Del Piano F; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy., Annunziata C; Department of Pharmacy, University of Naples Federico II, Naples, Italy., Comella F; Department of Pharmacy, University of Naples Federico II, Naples, Italy., Opallo N; Department of Pharmacy, University of Naples Federico II, Naples, Italy., Melini S; Department of Pharmacy, University of Naples Federico II, Naples, Italy., Grumetto L; Department of Pharmacy, University of Naples Federico II, Naples, Italy., Pirozzi C; Department of Pharmacy, University of Naples Federico II, Naples, Italy. Electronic address: claudio.pirozzi@unina.it., Mattace Raso G; Department of Pharmacy, University of Naples Federico II, Naples, Italy., Meli R; Department of Pharmacy, University of Naples Federico II, Naples, Italy., Ferrante MC; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2023 Jan 15; Vol. 313, pp. 121301. Date of Electronic Publication: 2022 Dec 16.
DOI: 10.1016/j.lfs.2022.121301
Abstrakt: Aims: Bisphenol A (BPA) is an endocrine-disrupting chemical inducing several damages such as neurotoxicity, immunotoxicity, and metabolic disorders. Obesity is the main risk factor for the increased occurrence of metabolic alterations as well as mood disorders. Here, we investigated in obese mice the effects of BPA on anxiety-like behavior, associated with neuroinflammation and immune activation.
Main Methods: Male C57Bl/6J mice were divided into 4 groups: control group (STD) receiving chow diet and BPA vehicle; STD group treated with BPA (50 μg/kg/die); high-fat diet (HFD) group receiving BPA vehicle; HFD group treated with BPA. BPA treatment started 12 weeks after HFD feeding and lasted 3 weeks.
Key Findings: The open field and elevated plus-maze tests showed in HFD + BPA group the worsening of HFD-induced anxiety-like behavior. The anxiogenic effects of BPA also emerged from hyperactivation of the hypothalamus-pituitary-adrenal gland axis, determined by the increased transcription of Crh and its receptor in the prefrontal cortex (PFC). Furthermore, BPA activated NLRP3 inflammasome and exacerbated the neuroinflammation induced by HFD, increasing IL-1β, TNF-α and monocyte chemoattractant protein (MCP)-1 in PFC. Furthermore, it induced inflammation and monocyte recruitment in hypothalamus and amygdala. Contextually, BPA significantly amplified the immune activation caused by lipid overload as evidenced by the increased expression of TLR-4 and MCP-1 in the PFC and triggered mastocytosis in the hypothalamus rather than STD mice.
Significance: All these data show that sub-chronic BPA exposure represents an additional risk factor for mood disorders strictly related to obesity, enhancing neuroinflammation and immune activation triggered by HFD feeding.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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