Resistance Exercise Training Increases Muscle Mass and Strength in Prostate Cancer Patients on Androgen Deprivation Therapy.

Autor:	Houben LHP, Overkamp M, VAN Kraaij P, Trommelen J; Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, THE NETHERLANDS., VAN Roermund JGH; Department of Urology, Maastricht University Medical Centre+, Maastricht, THE NETHERLANDS., DE Vries P; Department of Urology, Zuyderland Medical Centre, Heerlen, THE NETHERLANDS., DE Laet K; Department of Urology, Máxima Medical Centre, Veldhoven, THE NETHERLANDS., VAN DER Meer S; Department of Urology, Jeroen Bosch Hospital, 's-Hertogenbosch, THE NETHERLANDS., Mikkelsen UR; Arla Foods Ingredients Group P/S, Viby J, DENMARK., Verdijk LB, VAN Loon LJC, Beijer S, Beelen M
Jazyk:	angličtina
Zdroj:	Medicine and science in sports and exercise [Med Sci Sports Exerc] 2023 Apr 01; Vol. 55 (4), pp. 614-624. Date of Electronic Publication: 2022 Dec 14.
DOI:	10.1249/MSS.0000000000003095
Abstrakt:	Purpose: This study aimed to assess the effects of 20 wk resistance exercise training with or without protein supplementation on body composition, muscle mass, muscle strength, physical performance, and aerobic capacity in prostate cancer patients receiving androgen deprivation therapy (ADT). Methods: Sixty prostate cancer patients receiving ADT were randomly assigned to perform 20 wk of resistance exercise training with supplementation of 31 g whey protein (EX + PRO, n = 30) or placebo (EX + PLA, n = 30), consumed immediately after exercise and every night before sleep. A separate control group (CON, n = 36) only received usual care. At baseline and after 20 wk, body composition (dual-energy x-ray absorptiometry), muscle mass (computed tomography scan), muscle strength (1-repetition maximum strength tests), physical performance (Timed Up and Go Test, 30-Second Chair Stand Test, and Stair Climb Test), aerobic capacity (cardiopulmonary exercise test), and habitual dietary intake (food diary) were assessed. Data were analyzed using a two-factor repeated-measures ANOVA. Results: Over time, muscle mass and strength increased in EX + PRO and EX + PLA and decreased in CON. Total fat mass and fat percentage increased in EX + PRO and CON, but not in EX + PLA. Physical performance did not significantly change over time in either group. Aerobic capacity was maintained in EX + PLA, but it decreased in EX + PRO and CON. Habitual protein intake (without supplements) averaged >1.0 g·kg body weight -1 ·d -1 , with no differences over time or between groups. Conclusions: In prostate cancer patients, resistance exercise training counteracts the adverse effects of ADT on body composition, muscle mass, muscle strength, and aerobic capacity, with no additional benefits of protein supplementation. (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine.)
Databáze:	MEDLINE
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