| Autor: |
Srour B; Sorbonne Paris Nord University, Inserm U1153, Inrae U1125, Cnam, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center - University of Paris-Cité (CRESS) Bobigny France.; Nutrition And Cancer Research Network (NACRe Network) Jouy-en-Josas France., Chazelas E; Sorbonne Paris Nord University, Inserm U1153, Inrae U1125, Cnam, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center - University of Paris-Cité (CRESS) Bobigny France.; Nutrition And Cancer Research Network (NACRe Network) Jouy-en-Josas France., Fezeu LK; Sorbonne Paris Nord University, Inserm U1153, Inrae U1125, Cnam, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center - University of Paris-Cité (CRESS) Bobigny France., Javaux G; Sorbonne Paris Nord University, Inserm U1153, Inrae U1125, Cnam, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center - University of Paris-Cité (CRESS) Bobigny France., Pierre F; Nutrition And Cancer Research Network (NACRe Network) Jouy-en-Josas France.; Toxalim (Research Centre in Food Toxicology) Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS Toulouse France., Huybrechts I; Nutrition And Cancer Research Network (NACRe Network) Jouy-en-Josas France.; International Agency for Research on Cancer, World Health Organization Lyon France., Hercberg S; Sorbonne Paris Nord University, Inserm U1153, Inrae U1125, Cnam, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center - University of Paris-Cité (CRESS) Bobigny France.; Nutrition And Cancer Research Network (NACRe Network) Jouy-en-Josas France.; Public Health Department, Avicenne Hospital, AP-HP Bobigny France., Deschasaux-Tanguy M; Sorbonne Paris Nord University, Inserm U1153, Inrae U1125, Cnam, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center - University of Paris-Cité (CRESS) Bobigny France.; Nutrition And Cancer Research Network (NACRe Network) Jouy-en-Josas France., Kesse-Guyot E; Sorbonne Paris Nord University, Inserm U1153, Inrae U1125, Cnam, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center - University of Paris-Cité (CRESS) Bobigny France.; Nutrition And Cancer Research Network (NACRe Network) Jouy-en-Josas France., Touvier M; Sorbonne Paris Nord University, Inserm U1153, Inrae U1125, Cnam, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center - University of Paris-Cité (CRESS) Bobigny France.; Nutrition And Cancer Research Network (NACRe Network) Jouy-en-Josas France. |
| Abstrakt: |
Background Nitrates and nitrites are used as food additives in processed meats. They are also commonly ingested from water and several foods. Several short-term clinical studies suggested beneficial effects of dietary nitrates on blood pressure, while deleterious effects on oxidative damage have been suggested in some experimental studies. However, there is a lack of evidence from longitudinal epidemiological studies linking foods and water-originated and additives-originated nitrites and nitrates, separately, to hypertension and cardiovascular diseases risk. We aimed to study these associations in a large population-based cohort. Methods and Results Overall, 106 288 adults from the French NutriNet-Santé cohort (2009-2022) were included. Associations between nitrites and nitrates intakes and hypertension and cardiovascular disease risks were assessed using multi-adjusted Cox proportional hazard models. During follow-up, 3810 incident cases of hypertension and 2075 cases of cardiovascular diseases were ascertained. Participants with higher intakes of additives-originated nitrites (sodium nitrite in particular [European code e250]) had a higher hypertension risk compared with nonconsumers (hazard ratio, 1.19 [95% CI, 1.08-1.32], P =0.001, and 1.19 [95% CI, 1.08-1.32], P =0.002), respectively. No association was detected between foods and water-originated nitrites, or nitrates with hypertension risk (all P values >0.3). We found no association between nitrites or nitrates and risks of cardiovascular diseases (all P values >0.2). Conclusions These results do not support a protective role of nitrites or nitrates in cardiovascular health. Instead, they suggest a positive association between nitrites from food additives and hypertension risk, which needs confirmation in other large-scale studies. These findings provide new evidence in the context of current discussions about updating regulations on the use of nitrites as food additives. |
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