Human matters in asthma: Considering the microbiome in pulmonary health.

Autor:	Marathe SJ; Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States.; Division of Pulmonology, Allergy-Immunology, and Sleep, Memphis, TN, United States.; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN, United States., Snider MA; Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States.; Division of Emergency Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States., Flores-Torres AS; Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States.; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN, United States., Dubin PJ; Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States.; Division of Pulmonology, Allergy-Immunology, and Sleep, Memphis, TN, United States., Samarasinghe AE; Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States.; Division of Pulmonology, Allergy-Immunology, and Sleep, Memphis, TN, United States.; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2022 Dec 02; Vol. 13, pp. 1020133. Date of Electronic Publication: 2022 Dec 02 (Print Publication: 2022).
DOI:	10.3389/fphar.2022.1020133
Abstrakt:	Microbial communities form an important symbiotic ecosystem within humans and have direct effects on health and well-being. Numerous exogenous factors including airborne triggers, diet, and drugs impact these established, but fragile communities across the human lifespan. Crosstalk between the mucosal microbiota and the immune system as well as the gut-lung axis have direct correlations to immune bias that may promote chronic diseases like asthma. Asthma initiation and pathogenesis are multifaceted and complex with input from genetic, epigenetic, and environmental components. In this review, we summarize and discuss the role of the airway microbiome in asthma, and how the environment, diet and therapeutics impact this low biomass community of microorganisms. We also focus this review on the pediatric and Black populations as high-risk groups requiring special attention, emphasizing that the whole patient must be considered during treatment. Although new culture-independent techniques have been developed and are more accessible to researchers, the exact contribution the airway microbiome makes in asthma pathogenesis is not well understood. Understanding how the airway microbiome, as a living entity in the respiratory tract, participates in lung immunity during the development and progression of asthma may lead to critical new treatments for asthma, including population-targeted interventions, or even more effective administration of currently available therapeutics. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Marathe, Snider, Flores-Torres, Dubin and Samarasinghe.)
Databáze:	MEDLINE
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