Mapping Pulsatile Optic Nerve Head Deformation Using OCT.

Autor:	Solano MM; Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada.; Department of Ophthalmology. Université de Montréal, Montreal, Quebec, Canada., Richer E; Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada.; Department of Computer Engineering and Software Engineering, École Polytechnique de Montréal, Montreal, Quebec, Canada., Cheriet F; Department of Computer Engineering and Software Engineering, École Polytechnique de Montréal, Montreal, Quebec, Canada., Lesk MR; Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada.; Department of Ophthalmology. Université de Montréal, Montreal, Quebec, Canada., Costantino S; Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada.; Department of Ophthalmology. Université de Montréal, Montreal, Quebec, Canada.
Jazyk:	angličtina
Zdroj:	Ophthalmology science [Ophthalmol Sci] 2022 Aug 06; Vol. 2 (4), pp. 100205. Date of Electronic Publication: 2022 Aug 06 (Print Publication: 2022).
DOI:	10.1016/j.xops.2022.100205
Abstrakt:	Objective: To develop a noninvasive technique to quantitatively assess the pulsatile deformation due to cardiac contractions of the optic nerve head (ONH). Design: Evaluation of a diagnostic test or technology. Participants: Healthy subjects with no history of refractive surgery, divided into 2 cohorts on the basis of their axial length (AL). Methods: We present a noninvasive technique to quantitatively assess the pulsatile deformation of the ONH tissue by combining high-frequency OCT imaging and widely available image processing algorithms. We performed a thorough validation of the approach, numerically and experimentally, evaluating the sensitivity of the method to artificially induced deformation and its robustness to different noise levels. We performed deformation measurements in cohorts of healthy (n = 9) and myopic (n = 5) subjects in different physiological strain conditions by calculating the amplitude of tissue displacement in both the primary position and abduction. The head rotation was measured using a goniometer. During imaging in abduction, the head was rotated 40° ± 3°, and subjects were instructed to direct their gaze toward the OCT visual target. Main Outcome Measures: Pulsatile tissue displacement maps. Results: The robustness of the method was assessed using artificial deformations and increasing noise levels. The results show acceptable absolute errors before the noise simulations grossly exaggerate image degradation. For the group of subjects with AL of < 25 mm (n = 9), the median pulsatile displacement of the ONH was 7.8 ± 1.3 μm in the primary position and 8.9 ± 1.2 μm in abduction. The Wilcoxon test showed a significant difference ( P ≤ 0.005) between the 2 paired measures. Reproducibility was tested in 2 different sessions in 5 different subjects with the same intraocular pressure, and an intraclass correlation coefficient of 0.99 was obtained ( P < 0.005). Conclusions: The computational pipeline demonstrated good reproducibility and had the capacity to accurately map the pulsatile deformation of the optic nerve. In a clinical setting, we detected physiological changes in normal subjects supporting its translation potential as a novel biomarker for the diagnosis and progression of optic nerve diseases. (© 2022 by the American Academy of Ophthalmology.)
Databáze:	MEDLINE
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