Proteomic analysis of antiviral innate immunity.

Autor: Albarnaz JD; Cambridge Institute for Medical Research, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Weekes MP; Cambridge Institute for Medical Research, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK. Electronic address: mpw1001@cam.ac.uk.
Jazyk: angličtina
Zdroj: Current opinion in virology [Curr Opin Virol] 2023 Feb; Vol. 58, pp. 101291. Date of Electronic Publication: 2022 Dec 16.
DOI: 10.1016/j.coviro.2022.101291
Abstrakt: The capacity of host cells to detect and restrict an infecting virus rests on an array of cell-autonomous antiviral effectors and innate immune receptors that can trigger inflammatory processes at tissue and organismal levels. Dynamic changes in protein abundance, subcellular localisation, post-translational modifications and interactions with other biomolecules govern these processes. Proteomics is therefore an ideal experimental tool to discover novel mechanisms of host antiviral immunity. Additional information can be gleaned both about host and virus by systematic analysis of viral immune evasion strategies. In this review, we summarise recent advances in proteomic technologies and their application to antiviral innate immunity.
(Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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