The interaction between metaplastic neuromodulation and fatigue in multiple sclerosis.

Autor: Xian C; Discipline of Physiology, School of Biomedicine, The University of Adelaide, S433, Helen Mayo South, Frome Rd, 5005, South Australia, Australia., Barbi C; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Via Montelungo 7, 37131 Verona, Italy., Goldsworthy MR; Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), PO Box 11060, Adelaide 5001, South Australia, Australia., Venturelli M; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Via Montelungo 7, 37131 Verona, Italy., Sidhu SK; Discipline of Physiology, School of Biomedicine, The University of Adelaide, S433, Helen Mayo South, Frome Rd, 5005, South Australia, Australia. Electronic address: simran.sidhu@adelaide.edu.au.
Jazyk: angličtina
Zdroj: Journal of the neurological sciences [J Neurol Sci] 2023 Jan 15; Vol. 444, pp. 120521. Date of Electronic Publication: 2022 Dec 11.
DOI: 10.1016/j.jns.2022.120521
Abstrakt: Background and Objective: Neuromuscular fatigue contributes to decrements in quality of life in Multiple Sclerosis (MS), yet available treatments demonstrate limited efficacy. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique which presents promise in managing fatigue, possibly related to its capacity to modulate corticospinal excitability. There is evidence for capitalising on metaplasticity using tDCS for improving outcomes. However, this remains to be explored with fatigue in people with MS (pwMS). We investigated cathodal tDCS (ctDCS) priming on anodal tDCS (atDCS)-induced corticospinal excitability and fatigue modulation in pwMS.
Methods: 15 pwMS and 15 healthy controls completed fatiguing exercise whilst receiving either ctDCS or sham (stDCS) primed atDCS to the motor cortex. We assessed change in contraction force and motor evoked potential (MEP) amplitude across time to represent changes in fatigue and corticospinal excitability.
Results and Conclusion: ctDCS primed atDCS induced MEP elevation in healthy participants but not in pwMS, possibly indicating impaired metaplasticity in pwMS. No tDCS-mediated change in the magnitude of fatigue was observed, implying that development of fatigue may not rely on changes in corticospinal excitability.
Significance: These findings expand understanding of tDCS effects in pwMS, highlighting differences that may be relevant in the disease pathophysiology.
Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: