A systematic review of evidence for maternal preconception exposure to outdoor air pollution on Children's health.

Autor: Blanc N; University of Southern California, Los Angeles, CA, USA., Liao J; Department of Population and Public Health Sciences, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA., Gilliland F; Department of Population and Public Health Sciences, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA., Zhang JJ; Division of Environmental Science and Policy, Nicholas School of the Environment, Duke University, Durham, NC, USA; Duke Global Health Institute, Durham, NC, USA., Berhane K; Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA., Huang G; Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defect, Shanghai, China., Yan W; Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defect, Shanghai, China., Chen Z; Department of Population and Public Health Sciences, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA. Electronic address: zhanghuc@usc.edu.
Jazyk: angličtina
Zdroj: Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2023 Feb 01; Vol. 318, pp. 120850. Date of Electronic Publication: 2022 Dec 14.
DOI: 10.1016/j.envpol.2022.120850
Abstrakt: The preconception period is a critical window for gametogenesis, therefore preconception exposure to air pollutants may have long-term effects on children. We systematically reviewed epidemiological evidence concerning the effects of preconception ambient air pollution exposure on children's health outcomes and identified research gaps for future investigations. We searched PubMed and Web of Science from journal inception up to October 2022 based on an established protocol (PROSPERO: CRD42022277608). We then identified 162 articles based on searching strategy, 22 of which met the inclusion criteria. Studies covered a wide range of health outcomes including birth defects, preterm birth, birthweight, respiratory outcomes, and developmental outcomes. Findings suggested that exposure to outdoor air pollutants during maternal preconception period were associated with various health outcomes, of which birth defects has the most consistent findings. A meta-analysis revealed that during 3-month preconception period, a 10 μg/m 3 increase in PM 10 and PM 2.5 was associated with relative risk (RR) of birth defects of 1.06 (95% confidence interval (CI): 1.00, 1.02) and 1.14 (95% CI: 0.82, 1.59), respectively. Preterm birth, low birthweight, and autism have also been associated with maternal preconception exposure to PM 2.5 , PM 10 , O 3 and SO 2 . However, the significance of associations and effect sizes varied substantially across studies, partly due to the heterogeneity in exposure and outcome assessments. Future studies should use more accurate exposure assessment methods to obtain individual-level exposures with high temporal resolution. This will allow the exploration of which specific time window (weeks or months) during the preconception period has the strongest effect. In future epidemiologic studies, integrating pathophysiologic biomarkers relevant to clinical outcomes may help improve the causal inference of associations between preconception exposure and health outcomes suggested by the current limited literature. Additionally, potential effects of paternal preconception exposure need to be studied.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: