Resistance to mild cold stress is greater in both wild-type and long-lived GHR-KO female mice.

Autor: Fang Y; Department of Neurology, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Neuroscience Institute, Southern Illinois University School of Medicine, Springfield, IL, 62702, USA. yfang@siumed.edu., Medina D; Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, 62702, USA., Stockwell R; Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, 62702, USA., McFadden S; Department of Neurology, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Neuroscience Institute, Southern Illinois University School of Medicine, Springfield, IL, 62702, USA., Hascup ER; Department of Neurology, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Neuroscience Institute, Southern Illinois University School of Medicine, Springfield, IL, 62702, USA.; Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, 62702, USA., Hascup KN; Department of Neurology, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Neuroscience Institute, Southern Illinois University School of Medicine, Springfield, IL, 62702, USA.; Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, 62702, USA.; Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, 62702, USA., Bartke A; Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, 62702, USA.; Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, 62702, USA.
Jazyk: angličtina
Zdroj: GeroScience [Geroscience] 2023 Apr; Vol. 45 (2), pp. 1081-1093. Date of Electronic Publication: 2022 Dec 17.
DOI: 10.1007/s11357-022-00706-0
Abstrakt: Adapting to stress, including cold environmental temperature (eT), is crucial for the survival of mammals, especially small rodents. Long-lived mutant mice have enhanced stress resistance against oxidative and non-oxidative challenges. However, much less is known about the response of those long-lived mice to cold stress. Growth hormone receptor knockout (GHR-KO) mice are long-lived with reduced growth hormone signaling. We wanted to test whether GHR-KO mice have enhanced resistance to cold stress. To examine the response of GHR-KO mice to cold eT, GHR-KO mice were housed at mild cold eT (16 °C) immediately following weaning. Longevity results showed that female GHR-KO and wild-type (WT) mice retained similar lifespan, while both male GHR-KO and WT mice had shortened lifespan compared to the mice housed at 23 °C eT. Female GHR-KO and WT mice housed at 16 °C had upregulated fibroblast growth factor 21 (FGF21), enhanced energy metabolism, reduced plasma triglycerides, and increased mRNA expression of some xenobiotic enzymes compared to females housed at 23 °C and male GHR-KO and WT mice housed under the same condition. In contrast, male GHR-KO and WT mice housed at 16 °C showed deleterious effects in parameters which might be associated with their shortened longevity compared to male GHR-KO and WT mice housed at 23 °C. Together, this study suggests that in response to mild cold stress, sex plays a pivotal role in the regulation of longevity, and female GHR-KO and WT mice are more resistant to this challenge than the males.
(© 2022. The Author(s), under exclusive licence to American Aging Association.)
Databáze: MEDLINE
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