High performance of the automated ADVIA Centaur Systems SARS-CoV-2 Antigen Assay in nasopharyngeal samples with high viral load.

Autor: Ríos E; Department of Medicine, Facultad de Medicina, Universidad Complutense Madrid, Plaza Ramón y Cajal S/N, Madrid, 28040, Spain. erios02@ucm.es.; Department of Clinical Microbiology, Instituto de Investigación Sanitaria Hospital Clínico San Carlos, IdISSC, Madrid, Spain. erios02@ucm.es., Medrano S; Department of Clinical Microbiology, Instituto de Investigación Sanitaria Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Alvarez M; Department of Clinical Microbiology, Instituto de Investigación Sanitaria Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Valderrama MJ; Department of Genetics, Physiology and Microbiology, Faculty of Biology, Universidad Complutense de Madrid, Madrid, Spain., Vallejo L; Department of Clinical Microbiology, Instituto de Investigación Sanitaria Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Delgado-Iribarren A; Department of Medicine, Facultad de Medicina, Universidad Complutense Madrid, Plaza Ramón y Cajal S/N, Madrid, 28040, Spain.; Department of Clinical Microbiology, Instituto de Investigación Sanitaria Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Culebras E; Department of Medicine, Facultad de Medicina, Universidad Complutense Madrid, Plaza Ramón y Cajal S/N, Madrid, 28040, Spain.; Department of Clinical Microbiology, Instituto de Investigación Sanitaria Hospital Clínico San Carlos, IdISSC, Madrid, Spain.
Jazyk: angličtina
Zdroj: International microbiology : the official journal of the Spanish Society for Microbiology [Int Microbiol] 2023 Aug; Vol. 26 (3), pp. 471-474. Date of Electronic Publication: 2022 Dec 17.
DOI: 10.1007/s10123-022-00311-3
Abstrakt: ADVIA Centaur SARS-CoV-2 Antigen (COV2Ag) Assay (Siemens Healthineers) was evaluated for SARS-CoV-2 detection. A total of 141 nasopharyngeal samples were analyzed by this technique and results were compared with those obtained by quantitative reverse-transcription polymerase chain reaction (RT-PCR). The overall sensitivity and specificity of the test were 68.70% and 70%, respectively. Regarding cycle threshold (Ct) values, the COV2Ag test showed a sensitivity of 93.75% and 100% for nasopharyngeal samples with Ct < 25 and < 20, respectively. ADVIA Centaur COV2Ag Assay is a useful, automated, and rapid technique for early SARS-CoV-2 diagnosis and isolation of the infected individuals, avoiding its transmission.
(© 2022. The Author(s).)
Databáze: MEDLINE
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