Prevalence of type-1 interferon autoantibodies in adults with non-COVID-19 acute respiratory failure.

Autor: Ghale R; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, CA, USA.; Division of Infectious Diseases, University of California, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Spottiswoode N; Division of Infectious Diseases, University of California, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Anderson MS; Department of Medicine, University of California, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, CA, USA., Mitchell A; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA., Wang G; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA., Calfee CS; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA., DeRisi JL; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Langelier CR; Division of Infectious Diseases, University of California, San Francisco, CA, USA. chaz.langelier@ucsf.edu.; Department of Medicine, University of California, San Francisco, CA, USA. chaz.langelier@ucsf.edu.; Chan Zuckerberg Biohub, San Francisco, CA, USA. chaz.langelier@ucsf.edu.
Jazyk: angličtina
Zdroj: Respiratory research [Respir Res] 2022 Dec 16; Vol. 23 (1), pp. 354. Date of Electronic Publication: 2022 Dec 16.
DOI: 10.1186/s12931-022-02283-4
Abstrakt: Auto-antibodies (Abs) to type I interferons (IFNs) are found in up to 25% of patients with severe COVID-19, and are implicated in disease pathogenesis. It has remained unknown, however, whether type I IFN auto-Abs are unique to COVID-19, or are also found in other types of severe respiratory illnesses. To address this, we studied a prospective cohort of 284 adults with acute respiratory failure due to causes other than COVID-19. We measured type I IFN auto-Abs by radio ligand binding assay and screened for respiratory viruses using clinical PCR and metagenomic sequencing. Three patients (1.1%) tested positive for type I IFN auto-Abs, and each had a different underlying clinical presentation. Of the 35 patients found to have viral infections, only one patient tested positive for type I IFN auto-Abs. Together, our data suggest that type I IFN auto-Abs are uncommon in critically ill patients with acute respiratory failure due to causes other than COVID-19.
(© 2022. The Author(s).)
Databáze: MEDLINE
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