Increased visinin-like protein-1, YKL-40, lipocalin-2, and IL-23 levels in patients with migraine.

Autor:	Dündar A; Department of Medical Laboratory, Vocational School of Health Services, Mardin Artuklu University, Mardin, Turkey., Cafer V; Department of Neurology, Faculty of Medicine Istinye University, İstanbul, Turkey., Aslanhan H; Department of Family Medicine, Faculty of Medicine, Dicle University, Diyarbakır, Turkey., Özdemir HH; Department of Neurology, Ataköy Hospital, İstanbul, Turkey., Yilmaz A; Department of Family Medicine, Faculty of Medicine, Dicle University, Diyarbakır, Turkey., Çevik MU; Department of Neurology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
Jazyk:	angličtina
Zdroj:	Neurological research [Neurol Res] 2023 Feb; Vol. 45 (2), pp. 97-102. Date of Electronic Publication: 2022 Dec 16.
DOI:	10.1080/01616412.2022.2156125
Abstrakt:	Background: Migraine is a type of primary headache caused by changes in the trigeminal system and has been reported to be associated with neurovascular inflammation of cerebral and extracerebral vessels. Objective: It is known that inflammation is an important process in the pathogenesis of migraine. It has been shown that the molecules of visinin-like protein 1 (Vilip-1), YKL-40, lipocalin-2 and interleukin (IL)-23 play a role in the inflammatory process. Our aim is to investigate the role of this molecule in the metabolic pathway of migraine disease. Methods: Fifty migraine patients with and without aura in the interictal period were included in the study. Vilip-1, YKL-40, lipocalin-2, and IL-23 levels were measured by ELISA method. Results: Serum vilip-1, YKL-40, lipocalin-2, and IL-23 levels were found to be significantly higher in migraine patients compared to the control group. We found that this molecule increased significantly in migraine subgroups compared to the control group (p < 0.001). A positive significant correlation was found between vilip-1 level and YKL-40 and lipocalin-2 levels in migraine patients. In addition, a positive correlation was observed between visual analogue scale score, number of days with pain and vilip-1 level (p < 0.01). The results of our study showed that activation of inflammatory mediators may play a role in the pathogenesis of migraine disease. In addition, our study is valuable in that inflammatory molecules are high in the interictal period and these biomarkers have never been analyzed in migraine patients. However, we still believe that larger studies are needed to explain the role of vilip-1, YKL-40, lipocalin-2, and IL-23 in the molecular mechanism of migraine disease.
Databáze:	MEDLINE
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