| Autor: |
Liu Y; College of Pharmacy, Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, PR China., Liu Y; College of Pharmacy, Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, PR China., Zou HD; College of Pharmacy, Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, PR China., Zhou YQ; Guizhou University of Traditional Chinese Medicine, Guiyang, PR China., Pan J; College of Pharmacy, Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, PR China., Guan W; College of Pharmacy, Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, PR China., Algradi AM; College of Pharmacy, Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, PR China., Yang BY; College of Pharmacy, Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, PR China., Kuang HX; College of Pharmacy, Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, PR China. |
| Abstrakt: |
Three new steroids (1-3) and 13 reported analogs (4-16) were extracted from Datura metel L. pericarps. Structure analysis of these extracted compounds was performed by 1 D-NMR and 2 D-NMR spectroscopy, and their spectra were compared with those of similar compounds previously described in the literature. The extracted steroids (1-3) and known compounds (4-16) were evaluated for anti-inflammatory activity against LPS-activated RAW 264.7 cells. Compounds 5 , 7 , 9 , 12 and 15 showed potential anti-inflammatory activity with IC 50 less than 35 μM, while compounds 3 and 11 showed weak anti-inflammatory activity with IC 50 less than 100 μM. |
