Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications.

Autor: Swichkow CR; Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America., Bloom JS; Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California, United States of America.; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California, United States of America., Kruglyak L; Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California, United States of America.; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California, United States of America.
Jazyk: angličtina
Zdroj: PLoS biology [PLoS Biol] 2022 Dec 16; Vol. 20 (12), pp. e3001911. Date of Electronic Publication: 2022 Dec 16 (Print Publication: 2022).
DOI: 10.1371/journal.pbio.3001911
Abstrakt: Improvements to the production of proteins in industrial yeast species have largely relied on generating variation in a single genetic background. A new study in PLOS Biology leverages natural genetic variation to identify genes and variants with the potential to improve protein yield.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2022 Swichkow et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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