L-Arginine supplementation enhanced expression of glucose transporter (GLUT 1) in sickle cell anaemia subjects in the steady state.

Autor: Saka WA; Department of Physiology, Ladoke Akintola University of Technology, Ogbomosho, Nigeria., Anigbogu CN; Department of Physiology, College of Medicine, University of Lagos, Lagos, Nigeria., Kehinde MO; Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria., Jaja SI; Department of Physiology, College of Medicine, University of Lagos, Lagos, Nigeria.
Jazyk: angličtina
Zdroj: Current research in physiology [Curr Res Physiol] 2022 Dec 06; Vol. 6, pp. 100096. Date of Electronic Publication: 2022 Dec 06 (Print Publication: 2023).
DOI: 10.1016/j.crphys.2022.11.003
Abstrakt: L-Arginine may have therapeutic value in the management of sickle cell disease and diabetes mellitus. There is very little information on the interaction of GLUT 1 and L-Arginine in sickle cell disease subjects. This study compared the blood levels of Glut 1, fasting blood glucose (FBG) and fasting insulin (FIns) in non-sickle cell anaemia (HbAA) and sickle cell anaemia (HbSS) subjects in the steady state before and following L-Arginine supplementation (1 g/day for 6 weeks). Nitric oxide metabolites, (NO X ), catalase, superoxide dismutase and glutathione peroxidase were also measured in each group of subjects. Correlation coefficients between change (Δ) in Glut 1 and change (Δ) in FBG, Fins, NO X and antioxidant enzymes respectively were calculated. Before supplementation, Glut 1, NO X , GP X and CAT were significantly higher in HbAA subjects while FIns, FBG and MDA were higher in HbSS subjects. In both groups, supplementation significantly increased NO X , Glut 1 and antioxidant enzymes but decreased MDA. Supplementation increased FIns in HbAA but decreased FBG and FIns in HbSS subjects. In both groups of subjects, ΔGLUT 1 correlated positively with ΔNOX, antioxidant enzymes and Δ[R] but negatively with ΔMDA. ΔGLUT 1 correlated negatively with ΔFBG and ΔFins in HbSS but positively in HbAA. Study thus showed that in the steady state HbSS subjects had lower GLUT 1 but elevated FBG and Fins levels than HbAA subjects. Additionally, L-Arginine increased GLUT I and antioxidant enzymes but decreased Fins, FBG and MDA in HbSS subjects.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2022 Published by Elsevier B.V.)
Databáze: MEDLINE
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