Pluronic® triblock copolymer-based nanoformulations for cancer therapy: A 10-year overview.

Autor: de Castro KC; Faculty of Chemical Engineering, University of Campinas (UNICAMP), Campinas, Brazil., Coco JC; Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas, Brazil., Dos Santos ÉM; Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas, Brazil., Ataide JA; Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas, Brazil., Martinez RM; Faculty of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, Brazil., do Nascimento MHM; Center of Natural and Human Sciences, Federal University of ABC, Santo André, Brazil., Prata J; Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal; Associate Laboratory i4HB-Institute for Health and Bioeconomy at Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal., da Fonte PRML; Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal; Associate Laboratory i4HB-Institute for Health and Bioeconomy at Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal; Center for Marine Sciences (CCMAR), University of Algarve, Gambelas Campus, Portugal; Department of Chemistry and Pharmacy, Faculty of Sciences and Technology, University of Algarve, Gambelas Campus, 8005-139 Faro, Portugal., Severino P; Nanomedicine and Nanotechnology Laboratory (LNMed), Institute of Technology and Research (ITP) and Tiradentes University, Aracaju, Brazil., Mazzola PG; Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas, Brazil., Baby AR; Faculty of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, Brazil., Souto EB; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; REQUIMTE/UCIBIO, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal., de Araujo DR; Center of Natural and Human Sciences, Federal University of ABC, Santo André, Brazil., Lopes AM; Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas, Brazil. Electronic address: amlopes@unicamp.br.
Jazyk: angličtina
Zdroj: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2023 Jan; Vol. 353, pp. 802-822. Date of Electronic Publication: 2022 Dec 17.
DOI: 10.1016/j.jconrel.2022.12.017
Abstrakt: This paper provides a review of the literature on the use of Pluronic® triblock copolymers for drug encapsulation over the last 10 years. A special focus is given to the progress of drug delivery systems (e.g., micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, and polymersomes and niosomes); the beneficial aspects of Pluronic® triblock copolymers as biological response modifiers and as pharmaceutical additives, adjuvants, and stabilizers, are also discussed. The advantages and limitations encountered in developing site-specific targeting approaches based on Pluronic-based nanostructures in cancer treatment are highlighted, in addition to innovative examples for improving tumor cytotoxicity while reducing side effects.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: