Hsp70/Hsp90 Organising Protein (Hop): Coordinating Much More than Chaperones.

Autor:	Schwarz K; Biomedical Biotechnology Research Unit, Department of Biochemistry and Microbiology, Rhodes University, Makhanda/Grahamstown, South Africa., Baindur-Hudson S; Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia., Blatch GL; Biomedical Biotechnology Research Unit, Department of Biochemistry and Microbiology, Rhodes University, Makhanda/Grahamstown, South Africa.; Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia.; The Vice Chancellery, The University of Notre Dame Australia, Fremantle, WA, Australia.; Faculty of Health Sciences, Higher Colleges of Technology, Sharjah, UAE., Edkins AL; Biomedical Biotechnology Research Unit, Department of Biochemistry and Microbiology, Rhodes University, Makhanda/Grahamstown, South Africa. a.edkins@ru.ac.za.
Jazyk:	angličtina
Zdroj:	Sub-cellular biochemistry [Subcell Biochem] 2023; Vol. 101, pp. 81-125.
DOI:	10.1007/978-3-031-14740-1_3
Abstrakt:	The Hsp70/Hsp90 organising protein (Hop, also known as stress-inducible protein 1/STI1/STIP1) has received considerable attention for diverse cellular functions in both healthy and diseased states. There is extensive evidence that intracellular Hop is a co-chaperone of the major chaperones Hsp70 and Hsp90, playing an important role in the productive folding of Hsp90 client proteins, although recent evidence suggests that eukaryotic Hop is regulatory within chaperone complexes rather than essential. Consequently, Hop is implicated in many key signalling pathways, including aberrant pathways leading to cancer. Hop is also secreted, and it is now well established that Hop interacts with the prion protein, PrP C , to mediate multiple signalling events. The intracellular and extracellular forms of Hop most likely represent two different isoforms, although the molecular determinants of these divergent functions are yet to be identified. There is also a growing body of research that reports the involvement of Hop in cellular activities that appear independent of either chaperones or PrP C . While the various cellular functions of Hop have been described, its biological function remains elusive. However, recent knockout studies in mammals suggest that Hop has an important role in embryonic development. This review provides a critical overview of the latest molecular, cellular and biological research on Hop, critically evaluating its function in healthy systems and how this function is adapted in diseased states. (© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
Databáze:	MEDLINE
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