| Autor: |
Palacio TLN; Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil., Siqueira JS; Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil., de Paula BH; Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil., Rego RMP; Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil., Vieira TA; Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil., Baron G; Department of Pharmaceutical Sciences, University of Milan, Milan, Italy., Altomare A; Department of Pharmaceutical Sciences, University of Milan, Milan, Italy., Ferron AJT; Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil.; Department of Physical Education, Integrated Colleges of Bauru (FIB), Bauru, Brazil., Aldini G; Department of Pharmaceutical Sciences, University of Milan, Milan, Italy., Kano HT; Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil., Correa CR; Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil. |
| Abstrakt: |
Metabolic Syndrome (MetS), inflammation and oxidative stress contribute to impairment of skeletal muscle function. Bergamot ( Citrus bergamia ) leaf extract (BLE) has shown protective effects against comorbidities associated with MetS through its anti-inflammatory and antioxidant effects. The aim of this work was to elucidate the antioxidant and anti-inflammatory activity of BLE in skeletal muscles in an experimental model of MetS. Once metabolic syndrome was diagnosed, animals were divided into groups receiving different treatments for 10 weeks, including control diet ( n = 10), control + BLE ( n = 10), High Sugar-fat diet (HSF) ( n = 10), HSF + BLE ( n = 10). Evaluation included nutritional, metabolic and hormonal analyses, along with measurements of inflammatory status and oxidative stress in soleus and extensor digitorum longus (EDL) muscles. BLE showed positive metabolic effects, with a reduction of plasma triglycerides and insulin resistance and an increase in high-density lipoprotein cholesterol, and protective activity against oxidative stress and inflammation in Soleus and EDL muscles in animals with MetS. |
