Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents.

Autor: Mu X; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China., Cohen CA; HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong, China., Leung D; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China., Rosa Duque JS; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China., Cheng SMS; School of Public Health, The University of Hong Kong, Hong Kong, China., Chung Y; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China., Wong HHW; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China., Lee AMT; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China., Li WY; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China., Tam IYS; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China., Lam JHY; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China., Lee DHL; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China., Chan SM; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China., Tsang LCH; School of Public Health, The University of Hong Kong, Hong Kong, China., Chan KCK; School of Public Health, The University of Hong Kong, Hong Kong, China., Li JKC; School of Public Health, The University of Hong Kong, Hong Kong, China., Luk LLH; School of Public Health, The University of Hong Kong, Hong Kong, China., Chaothai S; School of Public Health, The University of Hong Kong, Hong Kong, China., Kwan KKH; School of Public Health, The University of Hong Kong, Hong Kong, China., Chu NC; School of Public Health, The University of Hong Kong, Hong Kong, China., Mori M; Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, Nonoichi, Japan., Jeevan T; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Kandeil A; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Webby RJ; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Tu W; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China. wwtu@hku.hk., Valkenburg SA; HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong, China. sophiev@hku.hk.; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia. sophiev@hku.hk., Peiris M; School of Public Health, The University of Hong Kong, Hong Kong, China. malik@hku.hk.; Centre for Immunology & Infection C2i, Hong Kong, China. malik@hku.hk., Lau YL; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China. lauylung@hku.hk.
Jazyk: angličtina
Zdroj: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2022 Dec 14; Vol. 7 (1), pp. 397. Date of Electronic Publication: 2022 Dec 14.
DOI: 10.1038/s41392-022-01282-7
Abstrakt: The high effectiveness of the third dose of BNT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies, but immune responses conferring this protection are not yet elucidated. In this analysis, our study (NCT04800133) aims to evaluate the humoral and cellular responses against wild-type and Omicron (BA.1, BA.2 and/or BA.5) SARS-CoV-2 before and after a third dose of BNT162b2 in healthy adolescents. At 5 months after 2 doses, S IgG, S IgG Fc receptor-binding, and neutralising antibody responses waned significantly, yet neutralising antibodies remained detectable in all tested adolescents and S IgG avidity increased from 1 month after 2 doses. The antibody responses and S-specific IFN-γ + and IL-2 + CD8 + T cell responses were significantly boosted in healthy adolescents after a homologous third dose of BNT162b2. Compared to adults, humoral responses for the third dose were non-inferior or superior in adolescents. The S-specific IFN-γ + and IL-2 + CD4 + and CD8 + T cell responses in adolescents and adults were comparable or non-inferior. Interestingly, after 3 doses, adolescents had preserved S IgG, S IgG avidity, S IgG FcγRIIIa-binding, against Omicron BA.2, as well as preserved cellular responses against BA.1 S and moderate neutralisation levels against BA.1, BA.2 and BA.5. Sera from 100 and 96% of adolescents tested at 1 and 5 months after two doses could also neutralise BA.1. Our study found high antibody and T cell responses, including potent cross-variant reactivity, after three doses of BNT162b2 vaccine in adolescents in its current formulation, suggesting that current vaccines can be protective against symptomatic Omicron disease.
(© 2022. The Author(s).)
Databáze: MEDLINE
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