Serum oxytocin and corticotropin-releasing hormone levels in the third trimester of pregnancy for predicting postpartum depression in Thai women.

Autor: Oon-Arom A; Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Suradom C; Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Srichairatanakool S; Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Luewan S; Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Petiwathayakorn T; Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Maneeton B; Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Maneeton N; Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Kawilapat S; Research Administration Section, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Srisurapanont M; Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. Electronic address: manit.s@cmu.ac.th.
Jazyk: angličtina
Zdroj: Asian journal of psychiatry [Asian J Psychiatr] 2023 Feb; Vol. 80, pp. 103392. Date of Electronic Publication: 2022 Dec 05.
DOI: 10.1016/j.ajp.2022.103392
Abstrakt: Purpose: This prospective observational study aimed to determine whether serum oxytocin (OT) or corticotrophin-releasing hormone (CRH) levels in the third trimester of pregnancy (or late pregnancy) could prospectively predict postpartum depression (PPD) at six weeks after childbirth.
Methods: We measured late pregnancy OT and CRH levels in Thai women, assessed depression using the Edinburgh Postnatal Depression Scale (EPDS) and Patient Health Questionnaire-9 (PHQ-9), and collected mothers, labor, and newborn data. At six weeks postpartum, an EPDS score ≥ 11 or PHQ-9 score ≥ 10 was defined as the presence of PPD. Multivariable binary logistic regression analysis was performed to determine the predictors of PPD.
Results: Of 200 participants, 136 (68.0%) were reassessed at six weeks postpartum, and 19 of them (14.0%) had PPD. Of the 19 participants with PPD, 9 met the EPDS criterion only, 3 met the PHQ-9 criterion only, and 7 met both criteria. OT levels were not significantly different between those with and without PPD (p = 0.35). CRH levels (aOR = 1.011, 95% CI = 1.001-1.023, p = 0.041), DASS-21 stress (aOR = 1.259, 95% CI = 1.132-1.400, p < 0.001), and APGAR at 1 min (aOR = 0.425, 95% CI = 0.240-0.752, p = 0.003) were significant predictors of PPD.
Conclusions: Only high CRH but not OT levels in late pregnancy may predict 6-week PPD. However, combining these CRH levels, late pregnancy stress, and newborn well-being immediately after birth seems to increase the accuracy of PPD prediction.
Competing Interests: Declaration of interest None.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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