Severe COVID-19 in patients with immune-mediated rheumatic diseases: A stratified analysis from the SORCOM multicentre registry.

Autor:	Boteanu A; Rheumatology Department and IRYCIS, Hospital Universitario Ramón y Cajal, Madrid, Spain., Leon L; Rheumatology Department and IDISSC, Hospital Clínico San Carlos, Madrid, Spain.; Health Sciences, Universidad Camilo José Cela, Madrid, Spain., Pérez Esteban S; Rheumatology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain., Rabadán Rubio E; Rheumatology Department, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain., Pavía Pascual M; Rheumatology Department, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain., Bonilla G; Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain., Bonilla González-Laganá C; Rheumatology Department, Hospital Universitario del Tajo, Aranjuez, Madrid, Spain., García Fernandez A; Rheumatology Department and IRYCIS, Hospital Universitario Ramón y Cajal, Madrid, Spain., Recuero Diaz S; Rheumatology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain., Ruiz Gutierrez L; Rheumatology Department, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain., Sanmartín Martínez JJ; Rheumatology Department, Hospital Universitario Severo Ochoa, Leganes, Madrid, Spain., de la Torre-Rubio N; Rheumatology Department, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain., Nuño L; Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain., Sánchez Pernaute O; Rheumatology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain., Del Bosque I; Rheumatology Department and IRYCIS, Hospital Universitario Ramón y Cajal, Madrid, Spain., Lojo Oliveira L; Rheumatology Department, Hospital Universitario Infanta Leonor, Madrid, Spain., Rodríguez Heredia JM; Rheumatology Department, Hospital Universitario de Getafe, Madrid, Spain., Clemente D; Rheumatology Department, Hospital Universitario Infantil Niño Jesus, Madrid, Spain., Abasolo L; Rheumatology Department and IDISSC, Hospital Clínico San Carlos, Madrid, Spain., Bachiller-Corral J; Rheumatology Department and IRYCIS, Hospital Universitario Ramón y Cajal, Madrid, Spain.; Universidad de Alcalá, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Modern rheumatology [Mod Rheumatol] 2023 Dec 22; Vol. 34 (1), pp. 97-105.
DOI:	10.1093/mr/roac148
Abstrakt:	Objectives: The aim of this study is to evaluate risk factors for severe coronavirus disease 2019 (COVID-19) in patients with immune-mediated rheumatic diseases, stratified by systemic autoimmune conditions and chronic inflammatory arthritis. Methods: An observational, cross-sectional multicentre study was performed. Patients from 10 rheumatology departments in Madrid who presented with severe acute respiratory syndrome coronavirus-2 infection between February 2020 and May 2021 were included. The main outcome was COVID-19 severity (hospital admission or mortality). Risk factors for severity were estimated, adjusting for covariates (socio-demographic, clinical, and treatments), using logistic regression analyses. Results: In total, 523 patients with COVID-19 were included, among whom 192 (35.6%) patients required hospital admission and 38 (7.3%) died. Male gender, older age, and comorbidities such as diabetes mellitus, hypertension, and obesity were associated with severe COVID-19. Corticosteroid doses >10 mg/day, rituximab, sulfasalazine, and mycophenolate use, were independently associated with worse outcomes. COVID-19 severity decreased over the different pandemic waves. Mortality was higher in the systemic autoimmune conditions (univariate analysis, P < .001), although there were no differences in the overall severity in the multivariate analysis. Conclusions: This study confirms and provides new insights regarding the harmful effects of corticosteroids, rituximab, and other therapies (mycophenolate and sulfasalazine) in COVID-19. Methotrexate and anti-tumour necrosis factor therapy were not associated with worse outcomes. (© Japan College of Rheumatology 2022. Published by Oxford University Press.)
Databáze:	MEDLINE
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