Pain, cancer-related distress, and physical and functional well-being among men with advanced prostate cancer.

Autor: Walsh EA; Department of Psychology, University of Miami, Coral Gables, FL, USA., Pedreira PB; Department of Psychology, University of Miami, Coral Gables, FL, USA., Moreno PI; Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA., Popok PJ; Department of Psychology, University of Miami, Coral Gables, FL, USA., Fox RS; College of Nursing, University of Arizona, Tucson, AZ, USA., Yanez B; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Antoni MH; Department of Psychology, University of Miami, Coral Gables, FL, USA.; Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA., Penedo FJ; Department of Psychology, University of Miami, Coral Gables, FL, USA. frank.penedo@miami.edu.; Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA. frank.penedo@miami.edu.
Jazyk: angličtina
Zdroj: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2022 Dec 14; Vol. 31 (1), pp. 28. Date of Electronic Publication: 2022 Dec 14.
DOI: 10.1007/s00520-022-07453-0
Abstrakt: Purpose: Men with advanced prostate cancer (APC) experience high levels of pain, which contribute to poor psychosocial and functional outcomes. Cancer-related distress explains the relationship between pain severity and interference, yet specificity of distress characteristics (e.g., hyperarousal, intrusive, or avoidant symptoms) in explaining associations between pain experiences and well-being has not been explored within APC. This study examined men with APC entering a clinical trial and tested associations of baseline pain, cancer-related distress, and physical and functional well-being.
Methods: One hundred ninety men with APC enrolled in a randomized-controlled trial and were assessed prior to randomization. The McGill Pain Questionnaire assessed pain severity, and the Functional Assessment of Cancer Therapy-General captures physical and functional well-being. The Impact of Events Scale-Revised measured cancer-specific distress symptoms, including hyperarousal, avoidance, and intrusion symptoms. Controlling for age, cancer stage at diagnosis, income, education, and race/ethnicity, mediation models (SPSS PROCESS, model 4) tested whether cancer-specific distress accounted for the associations between pain severity and physical and functional well-being.
Results: Men were on average 68 years of age, White non-Hispanic, with stage IV cancer. Pain severity was related to poorer physical (p < .001) and functional well-being (p < .001). Associations between pain severity and physical and functional well-being were partially mediated by greater intrusive and hyperarousal symptoms but not avoidant symptoms.
Conclusion: For men with APC, intrusive and hyperarousal symptoms may partially explain the relationship between pain severity and decrements in physical and functional well-being. APC pain management should attend to such distress symptoms, which may contribute to interference if left unaddressed.
Trial Registration: ClinicalTrials.gov Identifier: NCT03149185.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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