Reactogenicity of COVID-19 Vaccines in Patients With a History of COVID-19 Infection: A Survey Conducted in Pakistan.
| Autor: | Riyyan M; Medical Research Center, Liaquat University of Medical and Health Sciences, Jamshoro, PAK., Sarwar HA; Medicine and Surgery, Islam Medical College, Sialkot, PAK., Chania HA; Medical Research Center, Liaquat University of Medical and Health Sciences, Jamshoro, PAK., Sajid S; Medical Research Center, Liaquat University of Medical and Health Sciences, Jamshoro, PAK., Hotwani S; Medical Research Center, Liaquat University of Medical and Health Sciences, Jamshoro, PAK., Sarwar HU; Medicine and Surgery, Islam Medical College, Sialkot, PAK., Nawaz S; Medicine and Surgery, Islam Medical College, Sialkot, PAK., Abid S; Medical Research Center, Liaquat University of Medical and Health Sciences, Jamshoro, PAK. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2022 Nov 11; Vol. 14 (11), pp. e31359. Date of Electronic Publication: 2022 Nov 11 (Print Publication: 2022). |
| DOI: | 10.7759/cureus.31359 |
| Abstrakt: | Introduction As coronavirus disease 2019 (COVID-19) immunizations become more common, concerns about their safety and reactogenicity have grown. It is important to assess and analyze the post-vaccination side effects of several COVID-19 vaccines that have been licensed in Pakistan. Methods and results A comparative cross-sectional study was conducted between October 2021 and January 2022 to collect data on the side effects produced by different COVID-19 vaccines. An online survey was conducted to gather data on participants' demographics, clinical profiles, COVID-19 profiles as well as the intensity and side effects of COVID-19 vaccines. Statistical Package for the Social Sciences (SPSS) version 22.0 (IBM Corp., Armonk, NY) was used to analyze the data collected. Out of 421 participants, 63.2% were males, 36.8% of participants received messenger RNA (mRNA) vaccine, 33.2% received viral vector vaccine, 29.9% received inactivated vaccine, and further 71.7% of the total subjects were completely immunized. The majority of the symptoms were mild to moderate in degree. Approximately, 0.7% of the individuals reported experiencing serious adverse effects. Injection site pain (35.9%) was noted to be the most remarkable post-vaccination side effect followed by fever (33.2%) and fatigue (23.1%). Prior COVID-19 infection was not associated with the severity of any COVID-19 vaccine-related side effect (p > 0.05), except dyspnea. Younger participants and the female gender were substantially linked to post-vaccination adverse effects. Conclusion In comparison to viral vector and inactivated vaccines, our data suggest that the mRNA-based vaccination causes more severe adverse effects, and the majority of them were mild to moderate in severity. Participants who had previously contracted COVID-19 were not at a higher risk of developing additional vaccine-related side effects. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Riyyan et al.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|