Staphylococcus aureus extracellular adherence protein (Eap) reduces immune cell phenotype in developing but not in established atherosclerotic lesions.
Autor: | Salzmann M; Department of Internal Medicine II/Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; Ludwig Boltzmann Institute for Cardiovascular Research, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: manuel.salzmann@meduniwien.ac.at., Platzer H; Department of Internal Medicine II/Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: harald.platzer@meduniwien.ac.at., Mussbacher M; Department of Pharmacology and Toxicology, University of Graz, Humboldtstraße 46, 8010 Graz, Austria. Electronic address: marion.mussbacher@uni-graz.at., Derler M; Department of Pharmacology and Toxicology, University of Graz, Humboldtstraße 46, 8010 Graz, Austria. Electronic address: martina.derler@uni-graz.at., Lenz M; Department of Internal Medicine II/Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: max.lenz@meduniwien.ac.at., Haider P; Department of Internal Medicine II/Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: patrick.haider@meduniwien.ac.at., Brekalo M; Department of Internal Medicine II/Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: mira.brekalo@meduniwien.ac.at., Kral-Pointner JB; Department of Internal Medicine II/Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; Ludwig Boltzmann Institute for Cardiovascular Research, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: julia.pointner@meduniwien.ac.at., Kastl S; Department of Internal Medicine II/Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: stefan.kastl@meduniwien.ac.at., Speidl WS; Department of Internal Medicine II/Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; Ludwig Boltzmann Institute for Cardiovascular Research, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: walter.speidl@meduniwien.ac.at., Preissner KT; Department of Cardiology, Kerckhoff Heart Research Institute, Justus-Liebig-University, Aulweg 129, 35392 Giessen, Germany; Department of Biochemistry, Medical Faculty, Justus-Liebig-University, Friedrichstrasse 24, 35392 Giessen, Germany. Electronic address: klaus.t.preissner@biochemie.med.uni-giessen.de., Schubert U; Department of Biochemistry, Medical Faculty, Justus-Liebig-University, Friedrichstrasse 24, 35392 Giessen, Germany. Electronic address: uwe.schubert@biochemie.med.uni-giessen.de., Bischoff M; Institute of Medical Microbiology and Hygiene, Saarland University, Kirrberger Straße 100, 66424 Homburg, Germany. Electronic address: markus.bischoff@uks.eu., Uhrin P; Center for Physiology and Pharmacology, Schwarzspanierstraße 17A, 1090 Vienna, Austria. Electronic address: pavel.uhrin@meduniwien.ac.at., Wojta J; Department of Internal Medicine II/Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; Ludwig Boltzmann Institute for Cardiovascular Research, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: johann.wojta@meduniwien.ac.at., Hohensinner PJ; Ludwig Boltzmann Institute for Cardiovascular Research, Waehringer Guertel 18-20, 1090 Vienna, Austria; Center for Biomedical Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: philipp.hohensinner@meduniwien.ac.at. |
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Jazyk: | angličtina |
Zdroj: | Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2023 Mar; Vol. 1869 (3), pp. 166616. Date of Electronic Publication: 2022 Dec 10. |
DOI: | 10.1016/j.bbadis.2022.166616 |
Abstrakt: | Atherosclerosis is a chronic, inflammatory disease of the vessel wall where triggered immune cells bind to inflamed endothelium, extravasate and sustain local inflammation. Leukocyte adhesion and extravasation are mediated by adhesion molecules expressed by activated endothelial cells, like intercellular adhesion molecule 1 (ICAM-1). Extracellular adherence protein (Eap) from Staphylococcus aureus binds to a plethora of extracellular matrix proteins, including ICAM-1 and its ligands macrophage-1 antigen (Mac-1, α Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
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