Connexin 43 across the Vasculature: Gap Junctions and Beyond.

Autor:	Sedovy MW; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, 4 Riverside Circle, Roanoke, Virginia, USA.; Translational Biology, Medicine, And Health Graduate Program, Virginia Tech, Blacksburg, Virginia, USA., Leng X; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, 4 Riverside Circle, Roanoke, Virginia, USA., Leaf MR; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, 4 Riverside Circle, Roanoke, Virginia, USA.; Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA., Iqbal F; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, 4 Riverside Circle, Roanoke, Virginia, USA.; Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA., Payne LB; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, 4 Riverside Circle, Roanoke, Virginia, USA., Chappell JC; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, 4 Riverside Circle, Roanoke, Virginia, USA., Johnstone SR; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, 4 Riverside Circle, Roanoke, Virginia, USA.; Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, USA.
Jazyk:	angličtina
Zdroj:	Journal of vascular research [J Vasc Res] 2023; Vol. 60 (2), pp. 101-113. Date of Electronic Publication: 2022 Dec 13.
DOI:	10.1159/000527469
Abstrakt:	Connexin 43 (Cx43) is essential to the function of the vasculature. Cx43 proteins form gap junctions that allow for the exchange of ions and molecules between vascular cells to facilitate cell-to-cell signaling and coordinate vasomotor activity. Cx43 also has intracellular signaling functions that influence vascular cell proliferation and migration. Cx43 is expressed in all vascular cell types, although its expression and function vary by vessel size and location. This includes expression in vascular smooth muscle cells (vSMC), endothelial cells (EC), and pericytes. Cx43 is thought to coordinate homocellular signaling within EC and vSMC. Cx43 gap junctions also function as conduits between different cell types (heterocellular signaling), between EC and vSMC at the myoendothelial junction, and between pericyte and EC in capillaries. Alterations in Cx43 expression, localization, and post-translational modification have been identified in vascular disease states, including atherosclerosis, hypertension, and diabetes. In this review, we discuss the current understanding of Cx43 localization and function in healthy and diseased blood vessels across all vascular beds. (© 2022 S. Karger AG, Basel.)
Databáze:	MEDLINE
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