Direct Access to Unnatural Cyclobutane α-Amino Acids through Visible Light Catalyzed [2+2]-Cycloaddition.

Autor: Stinglhamer M; Organic Chemistry Institute, Westfälische-Wilhelms University Münster, Correnstraße 36, Münster 48149, Germany., Yzeiri X; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.; Institute of Chemistry of Organometallic Compounds, Via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy., Rohlfs T; Organic Chemistry Institute, Westfälische-Wilhelms University Münster, Correnstraße 36, Münster 48149, Germany., Brandhofer T; Organic Chemistry Institute, Westfälische-Wilhelms University Münster, Correnstraße 36, Münster 48149, Germany., Daniliuc CG; Organic Chemistry Institute, Westfälische-Wilhelms University Münster, Correnstraße 36, Münster 48149, Germany., García Mancheño O; Organic Chemistry Institute, Westfälische-Wilhelms University Münster, Correnstraße 36, Münster 48149, Germany.
Jazyk: angličtina
Zdroj: ACS organic & inorganic Au [ACS Org Inorg Au] 2022 Dec 07; Vol. 2 (6), pp. 496-501. Date of Electronic Publication: 2022 Aug 09.
DOI: 10.1021/acsorginorgau.2c00026
Abstrakt: In this work, we report the first selective, photocatalyzed [2+2]-cycloaddition of dehydroamino acids with styrene-type olefins. This simple, mild, and scalable approach relies on the use of the triplet energy transfer catalyst [Ir(dFCF 3 ppy 2 )dtbpy]PF 6 under visible light irradiation and provides fast access to value-added substituted strained cyclobutane α-amino acid derivatives.
Competing Interests: The authors declare no competing financial interest.
(© 2022 The Authors. Published by American Chemical Society.)
Databáze: MEDLINE
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