Neonatal exposure to ultrafine iron but not combined iron and sulfur aerosols recapitulates air pollution-induced impulsivity in mice.

Autor: Eckard ML; Department of Environmental Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA; Department of Psychology, Radford University, Radford, VA, USA. Electronic address: mleckard@radford.edu., Marvin E; Department of Environmental Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA., Conrad K; Department of Environmental Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA., Oberdörster G; Department of Environmental Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA., Sobolewski M; Department of Environmental Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA., Cory-Slechta DA; Department of Environmental Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA.
Jazyk: angličtina
Zdroj: Neurotoxicology [Neurotoxicology] 2023 Jan; Vol. 94, pp. 191-205. Date of Electronic Publication: 2022 Dec 09.
DOI: 10.1016/j.neuro.2022.12.004
Abstrakt: Air pollution (AP) is becoming recognized as a major threat to neurological health across the lifespan with increased risk of both neurodevelopmental and neurodegenerative disorders. AP is a complex mixture of gases and particulate matter, with adsorbed contaminants including metals and trace elements, which may differentially contribute to its neurodevelopmental impacts. Iron (Fe) is one of the most abundant metals found in AP, and Fe concentrations may drive some behavioral deficits observed in children. Furthermore, brains of neonate mice exposed to concentrated ambient ultrafine particulate matter (UFP) show significant brain accumulation of Fe and sulfur (S) supporting the hypothesis that AP exposure may lead to brain metal dyshomeostasis. The current study determined the extent to which behavioral effects of UFP, namely memory deficits and impulsive-like behavior, could be recapitulated with exposure to Fe aerosols with or without concomitant SO 2 . Male and female neonate mice were either exposed to filtered air or spark discharge-generated ultrafine Fe particles with or without SO 2 gas (n = 12/exposure/sex). Inhalation exposures occurred from postnatal day (PND) 4-7 and 10-13 for 4 hr/day, mirroring our previous UFP exposures. Mice were aged to adulthood prior to behavioral testing. While Fe or Fe + SO 2 exposure did not affect gross locomotor behavior, Fe + SO 2 -exposed females displayed consistent thigmotaxis during locomotor testing. Neither exposure affected novel object memory. Fe or Fe + SO 2 exposure produced differential outcomes on a fixed-interval reinforcement schedule with males showing higher (Fe-only) or lower (Fe + SO 2 ) response rates and postreinforcement pauses (PRP) and females showing higher (Fe-only) PRP. Lastly, Fe-exposed, but not Fe + SO 2 -exposed, males showed increased impulsive-like behavior in tasks requiring response inhibition with no such effects in female mice. These findings suggest that: 1) exposure to realistic concentrations of Fe aerosols can recapitulate behavioral effects of UFP exposure, 2) the presence of SO 2 can modulate behavioral effects of Fe inhalation, and 3) brain metal dyshomeostasis may be an important factor in AP neurotoxicity.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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