The antiaging effects of a product containing collagen and ascorbic acid: In vitro, ex vivo, and pre-post intervention clinical trial.

Autor: Ryu TK; Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.; Korean Skin Research Center, Seongnam, South Korea.; H&BIO Corporation/R&D Center, Seongnam, South Korea., Lee H; Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.; Korean Skin Research Center, Seongnam, South Korea.; H&BIO Corporation/R&D Center, Seongnam, South Korea., Yon DK; Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea., Nam DY; Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.; Korean Skin Research Center, Seongnam, South Korea.; H&BIO Corporation/R&D Center, Seongnam, South Korea., Lee SY; Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.; Korean Skin Research Center, Seongnam, South Korea.; H&BIO Corporation/R&D Center, Seongnam, South Korea., Shin BH; Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.; Korean Skin Research Center, Seongnam, South Korea.; H&BIO Corporation/R&D Center, Seongnam, South Korea., Choi GW; Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.; Korean Skin Research Center, Seongnam, South Korea.; H&BIO Corporation/R&D Center, Seongnam, South Korea., Jeon DS; Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.; Korean Skin Research Center, Seongnam, South Korea.; H&BIO Corporation/R&D Center, Seongnam, South Korea., Oh BB; Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.; Korean Skin Research Center, Seongnam, South Korea.; H&BIO Corporation/R&D Center, Seongnam, South Korea., Kim JH; Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.; Korean Skin Research Center, Seongnam, South Korea.; H&BIO Corporation/R&D Center, Seongnam, South Korea., Yoon Y; Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.; Korean Skin Research Center, Seongnam, South Korea.; H&BIO Corporation/R&D Center, Seongnam, South Korea., Kim HJ; Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.; Korean Skin Research Center, Seongnam, South Korea.; H&BIO Corporation/R&D Center, Seongnam, South Korea., Duteil L; Centre of Clinical Pharmacology Applied to Dermatology (CPCAD), Hôpital l'Archet 2, Nice, France., Bruno-Bonnet C; Weishardt International Group, Rond-Point Georges Jolimaître, Graulhet, France., Heo CY; Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.; Korean Skin Research Center, Seongnam, South Korea.; H&BIO Corporation/R&D Center, Seongnam, South Korea., Kang SM; Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.; Korean Skin Research Center, Seongnam, South Korea.; H&BIO Corporation/R&D Center, Seongnam, South Korea.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Dec 12; Vol. 17 (12), pp. e0277188. Date of Electronic Publication: 2022 Dec 12 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0277188
Abstrakt: Various substances, including collagen (Naticol®) and ascorbic acid, that inhibit and prevent skin aging have been studied. Collagen prevents skin aging, has anti-inflammatory effects, and assists in normal wound healing. Ascorbic acid is a representative antioxidant that plays a role in collagen synthesis. To achieve a synergistic effect of collagen and ascorbic acid on all skin types, we prepared a product named "TEENIALL." In addition, we used a container to separate ascorbic acid and collagen to prevent the oxidation of ascorbic acid. To confirm the effects of TEENIALL, we first confirmed its penetrability in fibroblasts, keratinocytes, melanocyte, and human skin tissues. Thereafter, we confirmed the collagen synthesis ability in normal human fibroblasts. Based on the results of in vitro tests, we conducted a clinical trial (KCT0006916) on female volunteers, aged 40 to 59 years, with skin wrinkles and hyperpigmentation, to evaluate the effects of the product in improving skin wrinkles, skin lifting, and pigmentation areas before using the product, and after 2 and 4 weeks of using the product. The values of nine wrinkle parameters that were evaluated decreased and those for skin sagging, pigmentation, dermal density, and mechanical imprint (pressure) relief were improved. Skin wrinkle and pigmentation were evaluated to ensure that the improvement effect was maintained even after 1 week of discontinuing the product use. The evaluation confirmed that the effects were sustained compared to those after 4 weeks of using the product. Additionally, skin wrinkles, skin lifting, radiance, and moisture content in the skin improved immediately after using the product once. Based on the results of in vitro and ex vivo experiments and the clinical trial, we show that the product containing ascorbic acid and collagen was effective in alleviating skin aging.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2022 Ryu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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