The combination of isomalto-oligosaccharides (IMO)-based dietary fiber and hypocaloric high-protein diet could improve the anthropometric profile and fasting plasma glucose of healthy adults: A repeated single-arm clinical trial.

Autor:	Wijaya H; Biomedical Laboratory, Faculty of Pharmacy, Widya Mandala Catholic University Surabaya, Jl. Kalisari Selatan No.1, Kalisari, Mulyorejo, Surabaya, East Java, 60112, Indonesia., Hirata Y; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan., Tjan LH; Department of Biomedic, School of Medicine, Universitas Ciputra, CitraLand CBD Boulevard, Surabaya, East Java, 60219, Indonesia., Tjahjono Y; Biomedical Laboratory, Faculty of Pharmacy, Widya Mandala Catholic University Surabaya, Jl. Kalisari Selatan No.1, Kalisari, Mulyorejo, Surabaya, East Java, 60112, Indonesia., Foe K; Biomedical Laboratory, Faculty of Pharmacy, Widya Mandala Catholic University Surabaya, Jl. Kalisari Selatan No.1, Kalisari, Mulyorejo, Surabaya, East Java, 60112, Indonesia., Caroline; Biomedical Laboratory, Faculty of Pharmacy, Widya Mandala Catholic University Surabaya, Jl. Kalisari Selatan No.1, Kalisari, Mulyorejo, Surabaya, East Java, 60112, Indonesia., Setiadi DA; Biomedical Laboratory, Faculty of Pharmacy, Widya Mandala Catholic University Surabaya, Jl. Kalisari Selatan No.1, Kalisari, Mulyorejo, Surabaya, East Java, 60112, Indonesia., Wihadmadyatami H; Department of Anatomy, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Jl. Fauna 2, Sleman, Yogyakarta, 55281, Indonesia., Novita BD; Faculty of Medicine, Widya Mandala Surabaya Catholic University, Jl. Kalisari Selatan No.1, Kalisari, Mulyorejo, Surabaya, East Java, 60112, Indonesia., Jong FHH; Faculty of Medicine, Widya Mandala Surabaya Catholic University, Jl. Kalisari Selatan No.1, Kalisari, Mulyorejo, Surabaya, East Java, 60112, Indonesia., Khudrati WC; Faculty of Medicine, Widya Mandala Surabaya Catholic University, Jl. Kalisari Selatan No.1, Kalisari, Mulyorejo, Surabaya, East Java, 60112, Indonesia.
Jazyk:	angličtina
Zdroj:	Contemporary clinical trials communications [Contemp Clin Trials Commun] 2022 Dec 05; Vol. 30, pp. 101049. Date of Electronic Publication: 2022 Dec 05 (Print Publication: 2022).
DOI:	10.1016/j.conctc.2022.101049
Abstrakt:	Background and Aims: Meals with high protein and fiber could reduce weight and improve diabetes risk factors. Isomalto-oligosaccharide (IMO), a form of dietary fiber, could induce the afferent signal that causes appetite suppression. However, the direct effect of fiber supplementation in the form of IMO combined with a high-protein diet (HPF) on those parameters is still unknown. This study aims to investigate the effect of HPF on anthropometric parameters and blood glucose regulation of healthy subjects. . Methods: Thirteen healthy subjects were given a hypocaloric high protein diet (HPD) mixed with their prepared meals for two weeks. Followed by the HPF diet for another two weeks. Their anthropometric parameters, such as body composition (total body weight, body fat percentage, and fat-free mass), BMI and waist circumference, and fasting plasma glucose, were measured. Results: Compared to pre-intervention, HPF could significantly (p ≤ 0.004) reduce the anthropometric parameters and fasting plasma glucose. Compared to HPD, HPF could significantly (p ≤ 0.005) reduce more total body weight, body fat percentage, and BMI. In addition, HPF could induce more satiety than HPD (higher VAS score). Conclusion: HPF could improve the subject's anthropometric parameters which is obviously beneficial in preventing the risk of developing diabetes. Competing Interests: The author declares no conflict of interest. (© 2022 The Author(s).)
Databáze:	MEDLINE
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