Association between PTCH1 and RAD54B Single-Nucleotide Polymorphisms and Non-syndromic Orofacial Clefts in the Northeast Population of Iran.

Autor: Morvaridi Farimani R; Department of Orthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Azimi-Nezhad M; Non-Communicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.; UMR, INSERM U 1122, IGE-PCV, Interaction Géne-Environment Enpathophysiologie Cardiovasculaire, Université De Lorraine, Nancy, France., KhorramKhorshid HR; Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran., Ebadifar A; Department of Orthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Dentofacial Deformities Research Center Research Institute of Dental Sciences, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Tohidkhah S; Tehran University of Medical Sciences, Tehran, Iran., Jafarian Z; Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran., Kamali K; Department of Public Health, Faculty of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran., Nazari Z; Non-Communicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran., Ebrahimzadeh-Vesal R; Pardis Genetic Laboratory, Mashhad, Iran.
Jazyk: angličtina
Zdroj: Avicenna journal of medical biotechnology [Avicenna J Med Biotechnol] 2022 Oct-Dec; Vol. 14 (4), pp. 310-316.
Abstrakt: Background: Non-Syndromic Cleft Lip with or without cleft Palate (NSCL/P) is a common developmental disorder of the head and neck with a multifactorial etiology. The current study aimed to evaluate the potential association of PTCH1 (rs10512248) and RAD54B (rs12681366) polymorphisms with NSCL/P in the Northeast Iranian population.
Methods: In the present study, blood samples were taken from 122 subjects with NSCL/P and 161 healthy controls. Polymerase Chain Reaction (PCR) followed by Restriction Fragment Length Polymorphism (RFLP) were used to conduct genotyping of single-nucleotide polymorphisms.
Results: Although differences were observed between cases and controls in rs10512248 and rs12681366, our data did not support a significant association of these polymorphisms with NSCL/P in our population.
Conclusion: Our findings suggest that polymorphisms of rs10512248 and rs12681366 may not be potential risk factors for NSCL/P in the Northeast Iranian population due to the multifactorial and multiethnicity characteristics of some genes.
(Copyright© 2022 Avicenna Research Institute.)
Databáze: MEDLINE
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