Development of Epstein-Barr virus-associated gastric cancer: Infection, inflammation, and oncogenesis.

Autor:	Iizasa H; Department of Microbiology, Shimane University Faculty of Medicine, Izumo 693-8501, Shimane, Japan., Kartika AV; Department of Microbiology, Shimane University Faculty of Medicine, Izumo 693-8501, Shimane, Japan.; Faculty of Medicine, Muslim University of Indonesia, Makassar 90231, Indonesia., Fekadu S; Department of Microbiology, Shimane University Faculty of Medicine, Izumo 693-8501, Shimane, Japan.; Department of Medical Microbiology and Parasitology, Hawassa University, College of Medicine and Health Science, Hawassa 1560, Ethiopia., Okada S; Department of Microbiology, Shimane University Faculty of Medicine, Izumo 693-8501, Shimane, Japan., Onomura D; Department of Microbiology, Shimane University Faculty of Medicine, Izumo 693-8501, Shimane, Japan., Wadi AFAA; Department of Microbiology, Shimane University Faculty of Medicine, Izumo 693-8501, Shimane, Japan., Khatun MM; Department of Microbiology, Shimane University Faculty of Medicine, Izumo 693-8501, Shimane, Japan., Moe TM; Department of Microbiology, Shimane University Faculty of Medicine, Izumo 693-8501, Shimane, Japan., Nishikawa J; Faculty of Laboratory Science, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan., Yoshiyama H; Department of Microbiology, Shimane University Faculty of Medicine, Izumo 693-8501, Shimane, Japan. yosiyama@med.shimane-u.ac.jp.
Jazyk:	angličtina
Zdroj:	World journal of gastroenterology [World J Gastroenterol] 2022 Nov 28; Vol. 28 (44), pp. 6249-6257.
DOI:	10.3748/wjg.v28.i44.6249
Abstrakt:	Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) cells originate from a single-cell clone infected with EBV. However, more than 95% of patients with gastric cancer have a history of Helicobacter pylori ( H. pylori ) infection, and H. pylori is a major causative agent of gastric cancer. Therefore, it has long been argued that H. pylori infection may affect the development of EBVaGC, a subtype of gastric cancer. Atrophic gastrointestinal inflammation, a symptom of H. pylori infection, is observed in the gastric mucosa of EBVaGC. Therefore, it remains unclear whether H. pylori infection is a cofactor for gastric carcinogenesis caused by EBV infection or whether H. pylori and EBV infections act independently on gastric cancer formation. It has been reported that EBV infection assists in the onco-genesis of gastric cancer caused by H. pylori infection. In contrast, several studies have reported that H. pylori infection accelerates tumorigenesis initiated by EBV infection. By reviewing both clinical epidemiological and experimental data, we reorganized the role of H. pylori and EBV infections in gastric cancer formation. Competing Interests: Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article. (©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu