Fall Risk, Sleep Behavior, and Sleep-Related Movement Disorders in Young Urbanites Exposed to Air Pollution.

Autor:	Calderón-Garcidueñas L; The University of Montana, Missoula, MT, USA.; Universidad del Valle de México, Mexico City, México., Kulesza R; Auditory Research Center, Lake Erie College of Osteopathic Medicine, Erie, PA, USA., Greenough GP; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover NH, USA., García-Rojas E; Universidad del Valle de México, Mexico City, México., Revueltas-Ficachi P; Universidad del Valle de México, Mexico City, México., Rico-Villanueva A; Universidad del Valle de México, Mexico City, México., Flores-Vázquez JO; Universidad del Valle de México, Mexico City, México., Brito-Aguilar R; Universidad del Valle de México, Mexico City, México., Ramírez-Sánchez S; Universidad del Valle de México, Mexico City, México., Vacaseydel-Aceves N; Emergency Department, Hospital San Angel Inn Sur, Mexico City, Mexico., Cortes-Flores AP; Universidad del Valle de México, Mexico City, México., Mansour Y; Department of Otolaryngology -Head and Neck Surgery, Henry Ford Macomb Hospital, Clinton Township, MI, USA., Torres-Jardón R; Instituto de Ciencias de la Atmósfera y Cambio Climático, Universidad Nacional, Autónoma de México, México., Villarreal-Ríos R; Universidad Autónoma de Piedras Negras, Piedras Negras, Coahuila, México., Koseoglu E; Neurology Department, Erciyes University, Kayseri, Turkey., Stommel EW; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover NH, USA., Mukherjee PS; Interdisciplinary Statistical Research Unit, Indian Statistical Institute, Kolkata, India.
Jazyk:	angličtina
Zdroj:	Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2023; Vol. 91 (2), pp. 847-862.
DOI:	10.3233/JAD-220850
Abstrakt:	Background: Quadruple aberrant hyperphosphorylated tau, amyloid-β, α-synuclein, and TDP-43 pathology had been documented in 202/203 forensic autopsies in Metropolitan Mexico City ≤40-year-olds with high exposures to ultrafine particulate matter and engineered nanoparticles. Cognition deficits, gait, equilibrium abnormalities, and MRI frontal, temporal, caudate, and cerebellar atrophy are documented in young adults. Objective: This study aimed to identify an association between falls, probable Rapid Eye Movement Sleep Behavior Disorder (pRBD), restless leg syndrome (RLS), and insomnia in 2,466 Mexican, college-educated volunteers (32.5±12.4 years). Methods: The anonymous, online study applied the pRBD and RLS Single-Questions and self-reported night-time sleep duration, excessive daytime sleepiness, insomnia, and falls. Results: Fall risk was strongly associated with pRBD and RLS. Subjects who fell at least once in the last year have an OR = 1.8137 [1.5352, 2.1426] of answering yes to pRBD and/or RLS questions, documented in 29% and 24% of volunteers, respectively. Subjects fell mostly outdoors (12:01 pm to 6:00 pm), 43% complained of early wake up hours, and 35% complained of sleep onset insomnia (EOI). EOI individuals have an OR of 2.5971 [2.1408, 3.1506] of answering yes to the RLS question. Conclusion: There is a robust association between falls, pRBD, and RLS, strongly suggesting misfolded proteinopathies involving critical brainstem arousal and motor hubs might play a crucial role. Nanoparticles are likely a significant risk for falls, sleep disorders, insomnia, and neurodegenerative lethal diseases, thus characterizing air particulate pollutants' chemical composition, emission sources, and cumulative exposure concentrations are strongly recommended.
Databáze:	MEDLINE
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