The Metabolic Role of Ketogenic Diets in Treating Epilepsy.

Autor:	Imdad K; Department of Biosciences, COMSATS University Islamabad, Islamabad 45550, Pakistan., Abualait T; College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia., Kanwal A; Department of Biosciences, COMSATS University Islamabad, Islamabad 45550, Pakistan., AlGhannam ZT; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia., Bashir S; Department of Biosciences, COMSATS University Islamabad, Islamabad 45550, Pakistan., Farrukh A; Department of General Medicine, Fauji Foundation Hospital, Rawalpindi 45000, Pakistan., Khattak SH; National Institute for Genomics and Advanced Biotechnology (N.I.G.A.B.), National Agriculture Research Centre (NARC), Islamabad 44000, Pakistan., Albaradie R; Neuroscience Center, King Fahad Specialist Hospital Dammam, Dammam 32253, Saudi Arabia., Bashir S; Neuroscience Center, King Fahad Specialist Hospital Dammam, Dammam 32253, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2022 Nov 29; Vol. 14 (23). Date of Electronic Publication: 2022 Nov 29.
DOI:	10.3390/nu14235074
Abstrakt:	Epilepsy is a long-term neurological condition that results in recurrent seizures. Approximately 30% of patients with epilepsy have drug-resistant epilepsy (DRE). The ketogenic diet (KD) is considered an effective alternative treatment for epileptic patients. The aim of this study was to identify the metabolic role of the KD in epilepsy. Ketone bodies induce chemical messengers and alterations in neuronal metabolic activities to regulate neuroprotective mechanisms towards oxidative damage to decrease seizure rate. Here, we discuss the role of KD on epilepsy and related metabolic disorders, focusing on its mechanism of action, favorable effects, and limitations. We describe the significant role of the KD in managing epilepsy disorders.
Databáze:	MEDLINE
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