Recurrence Rates for Pediatric Benign Ovarian Neoplasms.

Autor: Knaus ME; Center for Surgical Outcomes Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio; Division of Pediatric Surgery, Department of Surgery, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio., Onwuka AJ; Center for Surgical Outcomes Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio., Abouelseoud NM; Division of Pediatric and Adolescent Gynecology, Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Bergus KC; Center for Surgical Outcomes Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio; Division of Pediatric Surgery, Department of Surgery, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio., Breech LL; Division of Pediatric and Adolescent Gynecology, Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Brito KS; University of Chicago Pritzker School of Medicine, Chicago, Illinois., Dekonenko C; Department of Pediatric Surgery, Children's Mercy Hospital, Kansas City, Missouri., Hertweck SP; Division of Pediatric and Adolescent Gynecology, Norton Children's Gynecology, Louisville, Kentucky., Hong HY; Department of Obstetrics and Gynecology, University of California, Irvine, Irvine, California., Menon S; Department of Obstetrics and Gynecology, Medical College of Wisconsin, Children's Wisconsin, Milwaukee, Wisconsin., Merritt DF; Division of Pediatric and Adolescent Gynecology, Department of Obstetrics and Gynecology, Washington University School of Medicine in St. Louis, St. Louis Children's Hospital, St. Louis, Missouri., Schikler AG; University of Louisville School of Medicine, Louisville, Kentucky., Senapati N; Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, Michigan., Smith YR; Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, Michigan., Strickland JL; Division of Pediatric and Adolescent Gynecology, Department of Obstetrics and Gynecology, University of Missouri-Kansas City School of Medicine, Children's Mercy Hospital, Kansas City, Missouri., Truehart AI; Section of Family Planning, Department of Obstetrics and Gynecology, University of Chicago Medicine, Chicago, Illinois., Minneci PC; Center for Surgical Outcomes Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio; Division of Pediatric Surgery, Department of Surgery, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio., Hewitt GD; Division of Pediatric and Adolescent Gynecology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio. Electronic address: geri.hewitt@nationwidechildrens.org.
Jazyk: angličtina
Zdroj: Journal of pediatric and adolescent gynecology [J Pediatr Adolesc Gynecol] 2023 Apr; Vol. 36 (2), pp. 160-166. Date of Electronic Publication: 2022 Dec 08.
DOI: 10.1016/j.jpag.2022.11.006
Abstrakt: Study Objective: To examine the recurrence rates of pediatric benign ovarian neoplasms METHODS: A retrospective review of females up to 21 years of age who underwent surgery for a benign ovarian neoplasm at 8 pediatric hospitals from January 2010 through December 2016 was conducted. Data include primary operation details, follow-up imaging, and reoperation details.
Results: Four hundred and twenty-six females were included in our cohort, with a median age of 15 years at the time of the primary operation. Of the patients, 69% had a mature teratoma, 18% had a serous cystadenoma, and 8% had a mucinous cystadenoma. Two-thirds of patients underwent ovarian-sparing surgery. There were 11 pathologically confirmed recurrences (2.6%) at a median follow-up of 12.8 months. The pathologically confirmed recurrence was 10.5 per 100 person-months at 12 months (SE = 5.7) for mucinous cystadenomas and 0.4 months (SE = 0.4) for mature teratomas (P = .001). For half of the patients, the pathologically confirmed recurrences occurred by 12.8 months, and for 75%, they occurred by 23.3 months. There were no differences in reoperation or recurrence on the basis of initial procedure (ovary-sparing surgery vs oophorectomy).
Conclusion: We measured the pathologically confirmed recurrence rate for pediatric benign ovarian neoplasms in a large cohort. Oophorectomy was not protective against recurrence. Mucinous cystadenomas were at a greater risk of pathologically confirmed recurrence.
Competing Interests: Conflict of Interest Statement S. Paige Hertweck performs research with AbbVie Inc. regarding endometriosis. Diane F. Merritt and Yolanda R. Smith receive royalties from UpToDate Inc., unrelated to benign ovarian neoplasms.
(Copyright © 2022. Published by Elsevier Inc.)
Databáze: MEDLINE
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