Prevalence and distribution of aortic plaque by sex and age group among community-dwelling adults.

Autor: Qazi S; The National Heart, Lung and Blood Institute's (NHLBI) Framingham Heart Study, Framingham, MA, United States of America; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America. Electronic address: sqazi@bwh.harvard.edu., Gona PN; The National Heart, Lung and Blood Institute's (NHLBI) Framingham Heart Study, Framingham, MA, United States of America; Department of Exercise and Health Sciences, College of Nursing and Health Sciences, University of Massachusetts, Boston, MA, United States of America., Oyama-Manabe N; Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan., Salton CJ; Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, MA, United States of America., O'Donnell CJ; The National Heart, Lung and Blood Institute's (NHLBI) Framingham Heart Study, Framingham, MA, United States of America; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America., Manning WJ; Harvard Medical School, Boston, MA, United States of America; Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Department of Radiology Beth Israel Deaconess Medical Center, Boston, MA, United States of America., Chuang ML; Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.
Jazyk: angličtina
Zdroj: Clinical imaging [Clin Imaging] 2023 Feb; Vol. 94, pp. 79-84. Date of Electronic Publication: 2022 Dec 02.
DOI: 10.1016/j.clinimag.2022.11.019
Abstrakt: Rationale and Objectives: Atherosclerosis of the aorta is associated with increased risk of cardiovascular mortality and vascular events. We aim to describe the prevalence and distribution of non-calcified atherosclerotic plaque in the descending aorta as quantified by noncontrast cardiovascular magnetic resonance (CMR) in a community-dwelling cohort of adults.
Materials and Methods: We used CMR to quantify noncalcified aortic plaque in 1726 participants (aged 65 ± 9 years, 46.7% men) from the Cohort Study Offspring cohort. ECG-gated, fat-suppressed, T2-weighted, black blood turbo spin echo sequence was used to acquire 36 transverse slices covering the descending aorta from just below the arch to the aortoiliac bifurcation. Plaque was defined as discrete luminal protrusions ≥1 mm; these were manually traced, then summed to determine total descending aortic plaque (DAP) and segmental thoracic and abdominal aortic plaque (TAP, AAP). Participants were stratified by sex and age group (<55, 55-64, 65-74, ≥75y). A healthy referent group (without clinical cardiovascular disease, smoking, diabetes, impaired renal function; (N = 768, 43.8% men) was used to determine upper 90th percentile cutpoints for DAP and AAP which were then applied to the overall study cohort.
Results: Prevalence of DAP was similar between men (47.3%) and women (48.9%), p = 0.50, as was AAP prevalence (men: 44.5%, women: 46.7%, p = 0.16); TAP was less prevalent in both sexes (men: 8.9%, women: 7.1%, p = 0.15). Both prevalence and burden of DAP, AAP and TAP increased with advancing age.
Conclusion: Noncalcified plaque prevalence, visualized on CMR, in community-dwelling adults is similar between the sexes, and both prevalence and burden of aortic plaque increase with greater age.
Competing Interests: Declaration of competing interest None.
(Copyright © 2022. Published by Elsevier Inc.)
Databáze: MEDLINE
Externí odkaz: