Clinical proteomics towards multiomics in cancer.

Autor: Creighton CJ; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.; Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Jazyk: angličtina
Zdroj: Mass spectrometry reviews [Mass Spectrom Rev] 2024 Nov-Dec; Vol. 43 (6), pp. 1255-1269. Date of Electronic Publication: 2022 Dec 10.
DOI: 10.1002/mas.21827
Abstrakt: Recent technological advancements in mass spectrometry (MS)-based proteomics technologies have accelerated its application to study greater and greater numbers of human tumor specimens. Over the last several years, the Clinical Proteomic Tumor Analysis Consortium, the International Cancer Proteogenome Consortium, and others have generated MS-based proteomic profiling data combined with corresponding multiomics data on thousands of human tumors to date. Proteomic data sets in the public domain can be re-examined by other researchers with different questions in mind from what the original studies explored. In this review, we examine the increasing role of proteomics in studying cancer, along with the potential for previous studies and their associated data sets to contribute to improving the diagnosis and treatment of cancer in the clinical setting. We also explore publicly available proteomics and multi-omics data from cancer cell line models to show how such data may aid in identifying therapeutic strategies for cancer subsets.
(© 2022 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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