| Autor: |
Smirnov VS; MBRD 'Cytomed'., Slita AV; Influenza Research Institute., Garshinina AV; Influenza Research Institute., Belyaevskaya SV; Influenza Research Institute., Anikin AV; Influenza Research Institute., Zarubaev VV; Influenza Research Institute. |
| Jazyk: |
ruština |
| Zdroj: |
Voprosy virusologii [Vopr Virusol] 2016 Jun 28; Vol. 61 (3), pp. 125-131. Date of Electronic Publication: 2016 Jun 28. |
| DOI: |
10.18821/0507-4088-2016-61-2-125-131 |
| Abstrakt: |
In this work, the activity of glycyrrhizic acid (GL) and dipeptide alpha-glutamyl-tryptophane (EW) as single preparations or in combination (GL+EW) against experimental adenoviral infection in the syrian hamsters was studied. Application of gl and GL+EW was shown to decrease the level of the adenovirus replication in liver tissue by 0.6 - 1.2 lgTCID50 depending on the composition and time point of the post infection. It was also demonstrated that normalization of the structure of the liver tissue was required, which was shown on the level of both optical and electron microscopy. The results obtained in this work suggest that gl and GL+EW may be considered as potential component of the complex therapy of adenoviral infection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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