Chronic pain inhibits autophagy in hippocampus while the analgetic drug, Gabapentin reverts this SNI-driven action.

Autor: Guerreiro SR; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal., Guimarães MR; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal., Silva JM; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal., Dioli C; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal.; Institute of Biosciences and Applications, NCSR Demokritos, Athens, Greece., Vamvaka-Iakovou A; Institute of Biosciences and Applications, NCSR Demokritos, Athens, Greece., Sousa R; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal., Gomes P; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal., Megalokonomou A; Institute of Biosciences and Applications, NCSR Demokritos, Athens, Greece.; Medical School, University of Crete, Heraklion, Greece., Campos-Marques C; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal., Cunha AM; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal., Almeida A; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal., Sousa N; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal.; Clinical Academic Center (2CA), Braga, Portugal., Leite-Almeida H; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal. hugoalmeida@med.uminho.pt.; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal. hugoalmeida@med.uminho.pt., Sotiropoulos I; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal. ioannis@med.uminho.pt.; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal. ioannis@med.uminho.pt.; Institute of Biosciences and Applications, NCSR Demokritos, Athens, Greece. ioannis@med.uminho.pt.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2022 Nov; Vol. 27 (11), pp. 4371.
DOI: 10.1038/s41380-022-01874-3
Databáze: MEDLINE