Integrative perspective of the healthy aging process considering the metabolome, cardiac autonomic modulation and cardiorespiratory fitness evaluated in age groups.

Autor: De Favari Signini É; Department of Physiotherapy, Federal University of São Carlos, São Carlos, São Paulo, Brazil. signinietof@gmail.com., Castro A; Department of Chemistry, Federal University of São Carlos, São Carlos, São Paulo, Brazil., Rehder-Santos P; Department of Physiotherapy, Federal University of São Carlos, São Carlos, São Paulo, Brazil., Cristina Millan-Mattos J; Department of Physiotherapy, Federal University of São Carlos, São Carlos, São Paulo, Brazil., Magalhães de Oliveira J; Department of Chemistry, Federal University of São Carlos, São Carlos, São Paulo, Brazil., Minatel V; Department of Physiotherapy, Federal University of São Carlos, São Carlos, São Paulo, Brazil., Bianca Falasco Pantoni C; Department of Physiotherapy, Federal University of São Carlos, São Carlos, São Paulo, Brazil.; Department of Gerontology, Federal University of São Carlos, São Carlos, São Paulo, Brazil., Sobreiro Selistre de Araújo H; Department of Physiological Sciences, Federal University of São Carlos, São Carlos, São Paulo, Brazil., Fabrizzi F; Penápolis Educational Foundation (FUNEPE), Penápolis, São Paulo, Brazil., Porta A; Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.; Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, Policlinico San Donato, San Donato Milanese, Milan, Italy., Gilberto Ferreira A; Department of Chemistry, Federal University of São Carlos, São Carlos, São Paulo, Brazil., Vincenzi Oliveira R; Department of Chemistry, Federal University of São Carlos, São Carlos, São Paulo, Brazil., Maria Catai A; Department of Physiotherapy, Federal University of São Carlos, São Carlos, São Paulo, Brazil. mcatai@ufscar.br.; Cardiovascular Physical Therapy Laboratory, Department of Physical Therapy, Nucleus of Research in Physical Exercise, Federal University of São Carlos, Via Washington Luiz, Km 235, CP: 676, São Carlos, SP, 13565-905, Brazil. mcatai@ufscar.br.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Dec 09; Vol. 12 (1), pp. 21314. Date of Electronic Publication: 2022 Dec 09.
DOI: 10.1038/s41598-022-25747-5
Abstrakt: The aging process causes changes at all organic levels. Although metabolism, cardiac autonomic modulation (CAM), and cardiorespiratory fitness (CRF) are widely studied as a function of age, they are mainly studied in isolation, thus making it difficult to perceive their concomitant variations. This study aimed to investigate the integrated changes that occur in the metabolome, CAM, and CRF throughout aging in apparently healthy individuals. The subjects (n = 118) were divided into five groups according to age (20-29, 30-39, 40-49, 50-59, and 60-70 years old) and underwent blood collection, autonomic assessment, and a cardiopulmonary exercise test for metabolomics analysis using mass spectrometry and nuclear magnetic resonance, cardiac autonomic modulation analysis, and CRF by peak oxygen consumption analysis, respectively. The Tukey's post hoc and effect size with confidence interval were used for variables with a significant one-way ANOVA effect (P < 0.01). The main changes were in the oldest age group, where the CRF, valine, leucine, isoleucine, 3-hydroxyisobutyrate, and CAM reduced and hippuric acid increased. The results suggest significant changes in the metabolome, CAM, and CRF after the age of sixty as a consequence of aging impairments, but with some changes in the metabolic profile that may be favorable to mitigate the aging deleterious effects.
(© 2022. The Author(s).)
Databáze: MEDLINE
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