Aniba canelilla (Kunth) Mez essential oil and its primary constituent, 1-nitro-2-phenylethane, inhibits acetylcholinesterase and reverse memory impairment in rodents.

Autor: de Campos DL; Laboratório de Farmacologia da Inflamação e Comportamento, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil. Electronic address: daniele.dim94@gmail.com., Queiroz LY; Laboratório de Farmacologia da Inflamação e Comportamento, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil. Electronic address: leehyoshitome@gmail.com., Fontes-Junior EA; Laboratório de Farmacologia da Inflamação e Comportamento, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil. Electronic address: efontes@ufpa.br., Pinheiro BG; Centro de Ciências Biológicas, Universidade do Estado do Pará, 66087-662, Belém, PA, Brazil. Electronic address: brunogpinheiro1@gmail.com., da Silva JKR; Programa de Pós-Graduação em Química, Universidade Federal do Pará, 66075-900, Belém, PA, Brazil. Electronic address: joycekellys@ufpa.br., Maia CSF; Laboratório de Farmacologia da Inflamação e Comportamento, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil. Electronic address: crismaia@ufpa.br., Maia JGS; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil; Programa de Pós-Graduação em Química, Universidade Federal do Maranhão, 65080-040, São Luís, MA, Brazil. Electronic address: gmaia@ufpa.br.
Jazyk: angličtina
Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2023 Mar 01; Vol. 303, pp. 116036. Date of Electronic Publication: 2022 Dec 07.
DOI: 10.1016/j.jep.2022.116036
Abstrakt: Ethnopharmacological Relevance: Aniba canelilla, distributed in the Amazon region, stands out for its diverse economic and medicinal applications. Studies of the A. canelilla essential oil and its primary constituent, 1-nitro-2-phenylethane, have confirmed its anti-inflammatory, antinociceptive, anti-hypertensive potential, and anticholinesterase, among other therapeutic activities.
Aim of the Study: In addition, the present work aims to evaluate the potential of oil and NPE in the learning and memory of rodents.
Material and Methods: The oil was hydrodistilled and analyzed by GC and GC-MS. The learning and memory action in mice was evaluated through the scopolamine-induced cognitive deficit model, followed by behavioral analysis using Morris's water maze paradigm.
Results: Oil provided a yield of 0.5%, and in its chemical composition, 1-nitro-2-phenylethane (NPE) (76.2%) and methyleugenol (19.6%) were identified as primary constituents. Oil fractionation furnished NPE with 99.4%, which was used to evaluate its effects in animal models. Wistar rats were submitted to the mnemonic impairment-scopolamine-induced protocol for 7 days. The oil, NPE, and the positive control donepezil were administered from the 8th to 12th days. Morris water maze results demonstrated that oil and NPE reversed spatial learning and long-term memory similarly induced by muscarinic antagonist scopolamine to donepezil, the positive control.
Conclusion: These beneficial effects have led the work to further investigations of the oil and NPE to elucidate their pharmacological mechanism, focusing on the cholinergic pathway of the central nervous system and opening up to the knowledge of other adjacent mechanisms, whose results are still under analysis.
Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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