The Antinociceptive Effect of a Hydroalcoholic Extract of Polygala altomontana and Its Chemical Profile Using UPLC-ESI-QTOF-HR-MS.

Autor: Pradi L; Laboratory of Natural Products Chemistry, Department of Chemistry, Federal University of Santa Catarina, Campus Universitário-Trindade, 88040-900, Florianópolis, SC, Brazil., Andrade TES; Laboratory of Neurobiology of Pain and Inflammation, Department of Physiological Sciences, Federal University of Santa Catarina, Campus Universitário-Trindade, 88040-900, Florianópolis, SC, Brazil., Lacerda JWF; Laboratory of Natural Products Chemistry, Department of Chemistry, Federal University of Santa Catarina, Campus Universitário-Trindade, 88040-900, Florianópolis, SC, Brazil., Karvat J; Laboratory of Neurobiology of Pain and Inflammation, Department of Physiological Sciences, Federal University of Santa Catarina, Campus Universitário-Trindade, 88040-900, Florianópolis, SC, Brazil., Beppler LM; Laboratory of Neurobiology of Pain and Inflammation, Department of Physiological Sciences, Federal University of Santa Catarina, Campus Universitário-Trindade, 88040-900, Florianópolis, SC, Brazil., Tizziani T; Laboratory of Natural Products Chemistry, Department of Chemistry, Federal University of Santa Catarina, Campus Universitário-Trindade, 88040-900, Florianópolis, SC, Brazil., Santos ARS; Laboratory of Neurobiology of Pain and Inflammation, Department of Physiological Sciences, Federal University of Santa Catarina, Campus Universitário-Trindade, 88040-900, Florianópolis, SC, Brazil., Sandjo LP; Laboratory of Natural Products Chemistry, Department of Chemistry, Federal University of Santa Catarina, Campus Universitário-Trindade, 88040-900, Florianópolis, SC, Brazil.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2023 Jan; Vol. 20 (1), pp. e202200715. Date of Electronic Publication: 2022 Dec 23.
DOI: 10.1002/cbdv.202200715
Abstrakt: The hydroalcoholic extract of Polygala altomontana (30, 100, and 300 mg/kg, i.g.) showed a dose-dependent antinociceptive action during the inflammatory phase of the formalin test. In addition, the preparation (30 and 300 mg/kg, i.g.) showed anti-hyperalgesic action when tested on a mechanical nociception model. UPLC-ESI-QTOF-MS data indicated the active extract contained phenylpropanoid sucrose esters, glycosylated quercetin derivatives, styrylpyrones, and coumarins. Some identified compounds, including styrylpyrones and coumarins, have previously demonstrated antinociceptive action. The results also show that P. altomontana shows potential for developing pain-relieving herbal remedies and drugs.
(© 2022 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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