Glia of C. elegans coordinate a protective organismal heat shock response independent of the neuronal thermosensory circuit.

Autor:	Gildea HK; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Frankino PA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Tronnes SU; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Pender CL; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Durieux J; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Dishart JG; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Choi HO; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Hunter TD; Department of Biology, Howard University, Washington, DC, USA., Cheung SS; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Frakes AE; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Sukarto E; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Wickham K; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Dillin A; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2022 Dec 09; Vol. 8 (49), pp. eabq3970. Date of Electronic Publication: 2022 Dec 09.
DOI:	10.1126/sciadv.abq3970
Abstrakt:	Aging organisms lose the ability to induce stress responses, becoming vulnerable to protein toxicity and tissue damage. Neurons can signal to peripheral tissues to induce protective organelle-specific stress responses. Recent work shows that glia can independently induce such responses. Here, we show that overexpression of heat shock factor 1 ( hsf-1 ) in the four astrocyte-like cephalic sheath cells of Caenorhabditis elegans induces a non-cell-autonomous cytosolic unfolded protein response, also known as the heat shock response (HSR). These animals have increased lifespan and heat stress resistance and decreased protein aggregation. Glial HSR regulation is independent of canonical thermosensory circuitry and known neurotransmitters but requires the small clear vesicle release protein UNC-13. HSF-1 and the FOXO transcription factor DAF-16 are partially required in peripheral tissues for non-cell-autonomous HSR, longevity, and thermotolerance. Cephalic sheath glial hsf-1 overexpression also leads to pathogen resistance, suggesting a role for this signaling pathway in immune function.
Databáze:	MEDLINE
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